• Mendelian Randomization Supports a Causal Role for the Gut Microbiome in Longevity

    Updated: 2024-11-29 19:39:14
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 29th , 2024 Mendelian Randomization Supports a Causal Role for the Gut Microbiome in Longevity Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Animal and human data make a compelling case for differences in the gut microbiome between individuals to

  • Chronic Activation of cGAS-STING in Aged Macrophages Reduces Normal STING Response to Pathogens

    Updated: 2024-11-29 11:11:22
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 29th , 2024 Chronic Activation of cGAS-STING in Aged Macrophages Reduces Normal STING Response to Pathogens Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment In aged cells , mitochondrial dysfunction leads to mislocalization of mitochondrial DNA

  • Critiquing the Blue Zones

    Updated: 2024-11-29 11:11:18
    The idea that there are portions of the world in which lifestyle choice is leading to a sizable increase in life expectancy for large numbers of people, known as Blue Zones, is increasingly looking to be a mirage, the result of bad data and insufficiently skeptical analysis of that bad data. People are fascinated by longevity, credulous in the face of determined marketing, and Blue Zones have expanded as a cultural concept far beyond the limited evidence for their existence. People will be selling the Blue Zone concept long after the scientific community has written it off as one of many historical errors in epidemiology. Researchers have spent years identifying what are claimed to be methodological errors throughout the longevity literature. For Blue Zones, the […]

  • Cellular Copper Requirements as a Target for Cancer Therapies

    Updated: 2024-11-28 19:33:13
    In order to achieve meaningful progress in our lifetimes, the future of cancer therapy must become driven by a focus on common features that occur in all or near all cancers, and which are fundamental to the biology of cancer. Approaching the biochemistry of cancer in any other way leads to therapies that are only relevant to a small fraction of all cancers, targeting mechanisms that a tumor cell population is quite capable of evolving away from, given the selection pressure applied by the treatment. There are only so many researchers and only so much research funding. To find success in controlling cancer as a class of disease, future cancer therapies must have the potential to be very broadly applicable, to need minimal changes or […]

  • A Review of Phenotypic and Epigenetic Clocks

    Updated: 2024-11-28 11:22:15
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 28th , 2024 A Review of Phenotypic and Epigenetic Clocks Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Any sufficiently complex set of biological data can be used to build an aging clock via machine learning techniques , finding combinations of

  • Athletes Exhibit Better Working Memory than Sedentary People

    Updated: 2024-11-28 11:11:53
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 28th , 2024 Athletes Exhibit Better Working Memory than Sedentary People Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment A fair sized body of evidence shows that physical activity improves memory function both in the short term immediately following

  • Connecting the Aging of the Gut Microbiome to Thymic Involution and Immune System Dysfunction

    Updated: 2024-11-27 19:40:40
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 27th , 2024 Connecting the Aging of the Gut Microbiome to Thymic Involution and Immune System Dysfunction Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The composition of the gut microbiome the specific microbial species that are present and their

  • Accelerated Biological Age Measures Correlate With Cardiometabolic Disease Risk

    Updated: 2024-11-27 11:22:19
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 27th , 2024 Accelerated Biological Age Measures Correlate With Cardiometabolic Disease Risk Permalink With Comments Permalink No Comments Posted by Reason Read 2 Comments Add a Comment If measures of biological age are in fact reflections of the burden of damage and dysfunction making up

  • Sex Differences in Inflammation Driving Atherosclerosis

    Updated: 2024-11-27 11:11:54
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 27th , 2024 Sex Differences in Inflammation Driving Atherosclerosis Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Here find an interesting review of the sex differences observed in the development of atherosclerosis in humans . This condition , in

  • World's most common heart valve disease linked to insulin resistance in large national study

    Updated: 2024-11-27 05:41:49
    A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease -- aortic stenosis (AS).

  • Continued Investigation of Distinct Features of the Gut Microbiome in Long-Lived People

    Updated: 2024-11-26 19:34:22
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help November 26th , 2024 Continued Investigation of Distinct Features of the Gut Microbiome in Long-Lived People Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The composition of the gut microbiome the species present and their relative proportions , varies

  • Signals of inflammation during pregnancy linked to aging and memory changes 50 years later

    Updated: 2024-11-21 05:05:37
    A new study analyzed data from participants who have been followed for over 50 years, starting before their births. Researchers found that maternal immune activity during a critical period of sex-dependent brain development in pregnancy affected the offspring's long-term memory circuitry and function in childhood and midlife, with different patterns for males and females.

  • How educational attainment may impact memory and dementia risk later in life

    Updated: 2024-11-20 18:39:53
    Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a new study. The study compared the differences in years of education based on variations in state schooling mandates with cognitive performance outcomes in residents decades later.

  • Listening for early signs of Alzheimer's disease

    Updated: 2024-11-20 05:27:00
    People with Alzheimer's exhibit a loss of motor control along with cognitive decline, and one of the earliest signs of this decay can be spotted in involuntary eye movements known as saccades. These quick twitches of the eyes in Alzheimer's patients are often slower, less accurate, or delayed compared to those in healthy individuals. Researchers are exploring an alternative method using a more ubiquitous and less intrusive technology: earpiece microphones.

  • New study shows promising results for COPD treatment

    Updated: 2024-11-20 05:23:22
    A new study shows that a form of vitamin B3 can reduce lung inflammation in COPD patients. The researchers hope it will pave the way for new treatment options.

  • Cardiovascular drugs may reduce dementia risk

    Updated: 2024-11-19 23:16:56
    Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study.

  • Earlier diabetes diagnosis linked to dementia risk

    Updated: 2024-11-19 18:27:12
    People diagnosed with type 2 diabetes at a younger age are at a higher risk for developing dementia than those diagnosed later in life, according to a new study. The findings show that the increased risk is especially pronounced among adults with obesity.

  • Study identifies potential new drug for Parkinson's-related cognitive decline, dementia

    Updated: 2024-11-19 18:26:04
    A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.

  • Developing an antibody to combat age-related muscle atrophy

    Updated: 2024-11-19 18:25:57
    As we age, our muscles atrophy. Earlier this year, researchers found that hepatocyte growth factor (HGF), a protein critical in skeletal muscle development loses its functionality due to nitration as we age. Now, the same team has developed a monoclonal antibody that blocks the nitration sites of HGF, effectively preventing the protein's age induced loss of function. Their findings were validated utilizing rat muscles cell culture.

  • Free Personalized Health Assessment

    Updated: 2024-11-16 17:38:20
    The post Free Personalized Health Assessment appeared first on Anti Aging By Design | Live Younger Longer.

  • Researchers uncover potential treatment for rare genetic disorders

    Updated: 2024-11-14 18:02:14
    Researchers have identified a potential treatment for Sandhoff and Tay-Sachs diseases -- two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

  • Recycling in middle age may be critical for brain health

    Updated: 2024-11-14 05:58:19
    New research highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process have been linked to neurodegenerative disorders like Parkinson's and Alzheimer's disease, but until recently it was very challenging to study this process in the aging mammalian brain.

  • Treatment advances, predictive biomarkers stand to improve bladder cancer care

    Updated: 2024-11-14 00:30:20
    Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a new editorial.

  • MRI-guided radiation therapy reduces long-term side effects for patients with prostate cancer

    Updated: 2024-11-13 21:10:16
    After a comprehensive two-year follow-up, researchers found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.

  • Cell aging in one organ can snowball into multi-organ failure

    Updated: 2024-11-13 05:34:05
    The aging and failure of cells that occurs when one part of the body is damaged can spread to other organs, a study suggests.

  • Can everyday physical activity improve cognitive health in middle age?

    Updated: 2024-11-13 00:10:08
    Engaging in everyday physical activity has immediate benefits for brain health. Middle-aged people who participated in everyday movement showed improvement in cognitive processing speed equivalent to being four years younger, regardless of the activity's intensity.

  • Cognitive decline and loneliness linked in older adults over short time periods

    Updated: 2024-11-12 05:27:39
    Loneliness and cognitive performance were related in the short term for older adults, according to a new study.

  • Combination approach shows promise for treating rare, aggressive cancers

    Updated: 2024-11-12 05:27:32
    A research team has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

  • Age-related health decline a predictor of future dementia risk

    Updated: 2024-11-11 05:27:56
    A new study has found frailty increases a person's risk of dementia, but early intervention may be the key to prevention.

  • Older adult prostate cancer patients are increasingly being overtreated

    Updated: 2024-11-11 05:27:50
    Increasing percentages of some older U.S. men with intermediate-risk and high-risk prostate cancers are undergoing treatments that carry risks of side effects that can significantly reduce the quality of life without extending life, according to a new study. This trend is problematic because these men may not have life expectancies that would allow them to receive the benefits of more aggressive treatments.

  • Combat Aging... Anti-aging strategies for achieving lifelong fitness and health

    Updated: 2024-11-10 01:41:52
    Veteran consultant fed up with anti-aging hype, exposes the myths about aging. Discover how thousands of people combat aging, getting fitter, leaner, and stronger than they ever thought possible.

  • Prevalence of unrecognized cognitive impairment in socially and economically vulnerable older adults is high

    Updated: 2024-11-07 16:51:48
    One of the first studies to investigate the prevalence of unrecognized cognitive impairment among patients seen at Federally Qualified Health Centers, has found that it is ubiquitous, especially among minoritized older adults. These facilities provide primary care and preventive services regardless of ability to pay or health insurance status to more than 30 million patients, including a growing number of older adults.

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