Updated: 2024-10-15 19:19:26
Investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.
Updated: 2024-10-15 19:19:26
With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.
Updated: 2024-10-15 19:19:26
A new resource allows for studies of human longevity and resilience that can fuel the discovery and validation of novel therapeutics for aging-related disease.
Updated: 2024-10-15 19:19:26
With an aging population and fewer physicians available, the burden on rural communities is set to grow.
Updated: 2024-10-15 19:19:26
People whose diet more closely resembles the MIND diet may have a lower risk of cognitive impairment, according to a new study. Results were similar for Black and white participants. These results do not prove that the MIND diet prevents cognitive impairment, they only show an association.
Updated: 2024-10-15 19:19:26
A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.
Updated: 2024-10-15 19:19:26
A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults.
Updated: 2024-10-15 19:19:26
Two new papers by a team of researchers demonstrate that evaluating microRNAs in blood can be used not only to diagnose mild cognitive impairment (MCI) but also, critically, to predict the conversion from MCI to dementia due to Alzheimer's disease. Moreover, the researchers uncovered microRNA candidate molecular biomarkers that associate with current Amyloid, Tau, and Neurodegeneration (A/T/N) Alzheimer's biomarkers.
Updated: 2024-10-15 19:19:26
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
Updated: 2024-10-15 19:19:26
Scientists have discovered a novel way to lengthen the 'healthspan' of a women's ovaries -- improving maintenance of the ovaries and preventing key age-related changes in ovarian function. 'Healthspan' refers to the length of time a person remains healthy and free from serious illness or chronic diseases.
Updated: 2024-10-15 19:19:26
Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.
Updated: 2024-10-15 19:19:26
Outdoor light at night could be a significant risk factor in Alzheimer's disease, according to new research from Rush.
Updated: 2024-10-15 19:19:26
The risk of skin cancer for adults under the age of 50 is now decreasing for the first time in Sweden.
Updated: 2024-10-15 19:19:26
Findings from a new USC Dornsife study suggest that when older adults fall for financial scams, it could be an early warning sign of Alzheimer's disease. Researchers used MRI scans to find that older adults with thinner brain regions linked to memory and decision-making -- areas often affected early in Alzheimer's -- were more likely to be vulnerable to financial scams. The findings offer hope that financial vulnerability could be used as a simple screening tool to help identify early signs of cognitive decline, especially in people over 70.
Updated: 2024-10-15 19:19:26
A novel study addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults. In preclinical models, the research team found that anakinra, a drug typically used for inflammatory conditions such as rheumatoid arthritis, can be repurposed to block harmful signals between early lung cancer lesions and the bone marrow. This is critical, say the investigators, because as the immune system ages, it creates harmful inflammation that can drive cancer development.
Updated: 2024-10-15 19:19:26
Research discovered a unique and promising avenue for diagnosing Alzheimer's disease (AD) earlier -- by analyzing AD biomarkers in blood -- so that the impacts of dementia can be reduced. The researchers applied inorganic analytical geochemistry techniques, originally developed for cosmochemistry -- for example, to study the formation and evolution of the Earth, the Moon, other planets and asteroid samples -- and adapted these highly sensitive techniques to search for early biomarkers of AD in human blood serum.
Updated: 2024-10-15 19:19:26
Researchers are using works by Johann Sebastian Bach, along with MEG and MRI scans, to investigate how the brain compensates for age-related changes.
Updated: 2024-10-15 19:19:26
It turns out that a particular gene has a great influence on longevity, a new study concludes. This may pave the way for new treatment.
Updated: 2024-10-15 19:19:26
Scientists have discovered that coordination between basic cellular processes is lost with increasing age.
Updated: 2024-10-15 19:19:26
Aging is a major risk factor for neurodegenerative diseases, but the molecular mechanisms behind this relationship are not clear. In a recent study, researchers explored the role of PQBP3, a protein that helps stabilize the nuclear membrane, in cellular senescence and neurodegeneration. Their findings suggest that PQBP3 might be a promising therapeutic target for managing neurodegenerative diseases and the neuronal symptoms of aging.
Updated: 2024-10-15 18:22:25
The categorization of cell states into neat taxonomy is an attempt to conceptually simplify a much more complex, analog underlying reality. Any two cells in a given category may be different in ways that turn out to be meaningful in some contexts. So it should be taken as read that the senescent cells that grow in number with age and contribute to age-related disease differ from one another in many ways, and that what we call senescence is at present an oversimplified big tent. It may well turn out require separation into smaller categories to aid continued research and development into ways to reduce the impact of cellular senescence on later life health. Better understanding the many differences that can exist between any two given […]
Updated: 2024-10-15 10:22:23
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help October 15th , 2024 A Metabolomic Profile of Aging Derived from a Large Data Set Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Analysis of large omics data sets in the context of aging and mortality proceeds apace in the research community . On the one hand
Updated: 2024-10-15 10:01:01
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help October 15th , 2024 Demonstrating Glymphatic Drainage of Cerebrospinal Fluid in Humans Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Channels by which cerebrospinal fluid leaves the brain are important to long term health , as they allow removal of metabolic
Updated: 2024-10-14 18:44:57
Progress in medicine is painfully slow, in part thanks to the perverse incentives that drag down every heavily regulated field. But seven decades are left before we reach the closing years of this century. Seventy years in medicine is a long time. Consider what the medical science of the 1950s looked like in practice; consider what the treatment options looked like for common age-related diseases in that era, where they existed at all. Given that a longevity industry is just getting started, barely a decade old at this point, it seems a strange idea to bet against sizable gains in human life span before the end of the century. Even we play it safe and suggest that it will take a good 20 years or […]
Updated: 2024-10-14 10:22:29
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help October 14th , 2024 Immune Cells that Prevent Metastatic Cancer Cells from Proliferating After Migration Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment If there were a reliable way to prevent metastasis the spread of cancerous cells throughout the body and
Updated: 2024-10-14 10:11:43
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help October 14th , 2024 Exploring Causal Relationships Between Epigenetic Age and Neurodegenerative Disease Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers can use the strategy of Mendelian randomization to attempt to explore causation in human
Updated: 2024-10-11 17:05:00
Past studies have demonstrated that the economic cost of aging is enormous. It is not just a matter of the high medical cost of coping with a failing body and a panoply of conditions that cannot presently be cured or even much reversed. The lifetime cost of treating only cardiovascular disease is something like $750,000, for example. There is also the constant destruction of knowledge, capability, and ability to work. There is the opportunity cost of actions that cannot be taken. If everyone in the US gained a year of additional life, if aging was slowed by one year, $38 trillion in economic gains per year would be realized. These are staggering numbers. In today's open access papers, the authors take a different approach to […]
Updated: 2024-10-11 10:22:10
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help October 11th , 2024 Cellular Senescence in Endothelial Dysfunction Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment The interior of blood vessels is lined by the endothelium With aging , cells of the endothelium exhibit stress , inflammation , and altered
Updated: 2024-10-11 10:17:41
The metabolic responses to exercise and calorie restriction are so sweeping that there are many, many possible avenues by which drugs can mimic some of the effects. Researchers here try to get closer to the roots of these beneficial responses by using a molecule that will trigger the same reactions as two circulating signal molecules known to be important in regulating the response to exercise and fasting. This seems a reasonable strategy to try to capture a larger fraction of the benefits of exercise and fasting, but of course much more work is needed in order to see how this approach matches up to the sizable number of existing exercise mimetic and calorie restriction mimetic interventions. Elevation of the plasma levels of (S)-lactate (Lac) and/or […]
Updated: 2024-10-10 04:49:01
A new American Heart Association scientific statement suggests addressing cardiovascular health earlier in life may reduce the risk of stroke and help preserve thinking and memory later in life.
Updated: 2024-10-09 22:35:48
A new study has found some cancers to be slightly more frequent in people with multiple sclerosis (MS) than in people without MS. Types of cancers found to have a small increased risk include bladder, brain and cervical cancers. The study does not prove that MS increases a person's risk of cancer. It only shows an association.
Updated: 2024-10-09 04:13:47
Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.
Updated: 2024-10-08 02:27:58
Markers of cellular aging -- such as DNA damage response, cellular senescence, and inflammatory pathways -- significantly increased in all breast cancer survivors, regardless of the type of treatment received.
Updated: 2024-10-07 15:49:24
After nearly doubling over the 20th century, the rate of increase in life expectancy has slowed considerably in the last three decades, according to a new study.
Updated: 2024-10-03 18:54:29
Researchers have identified individuals with increased risk for dementia using mobility data, recorded during a smartphone-based way-finding task on the university campus. The findings show the potential of smartphone data, collected in conditions close to everyday life, for the early detection and monitoring of Alzheimer's disease. The study included 72 adults; about a third of them with subjective cognitive decline (SCD), a condition that is a known risk factor for dementia.
Updated: 2024-10-02 14:47:11
The time of day when blood is taken can affect the results of tests for diagnosing dementia, according to new research.
