Updated: 2024-06-28 10:22:51
There are many ways to construct a measure of biological age. Any form of complex data that varies over the course of aging will suffice. Machine learning can determine algorithmic combinations of measured values that correlate with age, and then one can assess the biological age of an individual by seeing where they fit into the established trend. Here, researchers advocate for the use of protein aggregate levels as the underlying data upon which to build a clock. Many different proteins can aggregate with advancing age, and tend to do so to a greater degree in later life, so this data could be used to build novel clocks with which to measure biological age. As we age, the DNA and proteins that make up our […]
Updated: 2024-06-28 10:03:39
Clocks to measure biological age can be constructed from any sufficiently large set of biological data that changes with age. The first such clocks used DNA methylation at a range of CpG sites on the genome. The primary challenge in the use of these clocks is that there is no well established link between specific mechanisms of aging and the clock data. For epigenetic clocks built on DNA methylation data, for example, it is not well understood how the methylation status of specific CpG sites on the genome is determined, so it is presently impossible to understand exactly why the clock gives the result that it does. An alternative approach is to construct clocks from clinical measures that are already well connected to specific mechanisms […]
Updated: 2024-06-27 18:35:00
Aging Biotech Info is a curated set of lists related to the aging-focused biotechnology field, maintained by one of the investors in the space and a coterie of helpful volunteers. The site started with companies and conferences, and has expanded from there. Maintaining lists in a rapidly moving field of research and commercial development is harder than it looks, and the effort is appreciated. The latest list to be added in a first pass form is an ambitious effort, as it aims to say something about the presently available therapies that are thought to slow or reverse aging, for some definition of "available", and some consensus on the evidence needed for a therapy to be thought to slow or reverse aging. People tend to have […]
Updated: 2024-06-27 10:22:40
For those people who are not participating in the obesity epidemic or otherwise sabotaging their prospects for long-term health, remaining life expectancy at any given adult age is slowly increasing over time. Each generation could expect to live a few years longer than the prior generation. We live in an age of technological progress in the life sciences, and so the state of medicine advances to ever greater capabilities, even given the ball and chain of excessive regulatory costs. That said, we do have the choice to live better or live worse, and those choices do have an impact regardless of the technological environment we find ourselves in. This open access paper puts some numbers to the long-term consequences of better versus worse choices when […]
Updated: 2024-06-27 10:13:42
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help June 27th , 2024 The Role of Microglia in Cognitive Impairment Following Stroke Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Microglia are innate immune cells of the central nervous system analogous to the macrophages that serve the same role elsewhere in
Updated: 2024-06-26 18:18:55
Neurogenesis is the creation of new neurons from neural stem cell populations and their integration into existing neural networks in the brain, a process thought to be essential to memory, learning, and the limited recovery of the brain from injury. It is presently the consensus position in the research community that neurogenesis does takes place in the adult brain, not just during development, but this hasn't always been the case, and it remains a topic for some debate over the fine details. This is particularly the case because so much of the work relies on data obtained in mice and rats. Obtaining equivalent data from living human brains is challenging, and such data makes up very little of the supporting evidence for the present consensus. […]
Updated: 2024-06-26 10:22:09
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help June 26th , 2024 Blocking cGAS-STING Inflammatory Signaling Protects the Retina for Glaucoma Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here provide evidence for retinal degeneration to be driven in part by maladaptive innate immune signaling
Updated: 2024-06-26 10:11:56
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help June 26th , 2024 In Search of Regulators of Transposon Activity Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Transposable elements or transposons , are DNA sequences in the genome capable of hijacking transcriptional machinery to copy themselves into new
Updated: 2024-06-25 10:22:59
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help June 25th , 2024 Modeling Extended Maternal Care and the Evolution of Longer Lives in Mammals Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The grandmother hypothesis suggests that human longevity relative to other primates and large mammals evolved because
Updated: 2024-06-21 21:23:52
Our bone marrow the fatty, jelly-like substance inside our bones is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells that generate all of the various types of blood cells in our bodies and regenerating themselves to keep the entire assembly line of blood production operating smoothly.
Updated: 2024-06-21 04:28:37
While previous studies suggested an association of the most common cerebral small-vessel disease with dementia risk, new research provides evidence of causal link, identifying it as a major vascular factor.
Updated: 2024-06-21 04:28:02
Researchers have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models. If these findings are confirmed in clinical studies, there may be therapeutic implications for age-related diseases such as Alzheimer's, Parkinson's, heart disease and cancer.
Updated: 2024-06-21 04:27:57
Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.
Updated: 2024-06-20 19:23:09
Women who have their ovaries removed before menopause, particularly before the age of 40, have reduced white matter integrity in multiple regions of the brain later in life, a new study suggests. White matter refers to the nerve fibers that connect neurons in different areas of the brain.
Updated: 2024-06-19 22:23:31
Certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB), according to a new study. The researchers think that a specific side effect of the drugs targets a biological flaw shared by DLB and other neurodegenerative diseases, raising the possibility that they may have broad potential for treating a wide range of neurodegenerative conditions.
Updated: 2024-06-18 15:56:24
Telo-seq -- a new tool -- is bringing telomere science into its modern era. Scientists can finally explore questions about the role of telomeres in aging and cancer that were not accessible with previous methods. The findings will inspire novel telomere-targeting therapeutics for aging-related diseases.
Updated: 2024-06-18 15:53:27
The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.
Updated: 2024-06-17 21:37:22
The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. While uncovering how the high fat, low carbohydrate diet boosts memory in older mice, scientists identified a new molecular signaling pathway that improves synapse function and helps explain the diet's benefit on brain health and aging.
Updated: 2024-06-17 21:35:55
A pioneering study has unveiled significant heterogeneity in the risk factors affecting healthy aging in Latin America and emphasized the limitations of current models of brain health, which are primarily based on data from high-income countries.
Updated: 2024-06-17 21:35:18
A new study has highlighted the widespread use of physical restraints among caregivers of older adults with advanced dementia living at home, revealing a need for better guidance and alternative care approaches.
Updated: 2024-06-17 21:34:33
Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases? Researchers propose the concept of a 'protein aggregation clock' to measure aging and health.
Updated: 2024-06-17 21:34:08
A new aging atlas gives scientists an in-depth view of how individual cells and tissues in worms age and how different lifespan-extending strategies might stop the clock.
Updated: 2024-06-12 21:31:16
People who give birth to infants less than 5.5 pounds may be more likely to have memory and thinking problems later in life than people who give birth to infants who do not have a low birth weight, according to a new study. The effect on memory and thinking skills was equivalent to one to two years of aging for those with low-birth-weight deliveries.
Updated: 2024-06-12 18:08:27
Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.
Updated: 2024-06-06 19:23:10
A searchable database is now ready to help study Alzheimer's disease. Neuroscience and biomedical informatics researchers have created the comprehensive, user-friendly repository.
Updated: 2024-06-06 19:21:24
In an advance that could improve bladder cancer treatment, a novel combination of cretostimogene grenadenorepvec and pembrolizumab has shown remarkable efficacy in patients with Bacillus Calmette-Gu rin (BCG)-unresponsive non-muscle invasive bladder cancer. Results from the phase 2 CORE-001 trial reveal a significant improvement in complete response rates and long-term disease control, offering new hope for patients with this challenging condition who face limited treatment options.
Updated: 2024-06-03 15:40:36
Researchers have discovered numerous age-related changes in the lipid metabolism of mice, across both organs and sexes. Among these changes was the selective accumulation, throughout the body, of certain lipids produced by gut bacteria as the mice aged. They also discovered a sex difference in the kidneys and a gene responsible for it. This study could lead to better understanding of chronic age-related conditions like Alzheimer's disease, atherosclerosis, kidney disease, and cancer.
