Updated: 2024-08-30 18:14:19
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help August 30th , 2024 p53 in Aging and Senescence Across Species Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The traditional view of the p53 tumor suppressor gene is that it is a representative mechanism in the evolved trade-off between suppression of cancer
Updated: 2024-08-30 10:22:16
Most of the present forms of assessment of biological age are based on immune cell characteristics in a blood sample. In this paper, researchers look at some of the differences in the biology of mice versus humans that may be relevant to the way in which we should think about animal data versus human data and the utility of various aging clocks. How much can one infer potential utility in humans based on data obtained from mice, and how does that vary by approach to biological age assessment? Aging significantly impacts the hematopoietic system, reducing its regenerative capacity and ability to restore homeostasis after stress. Mouse models have been invaluable in studying this process due to their shorter lifespan and the ability to explore genetic, […]
Updated: 2024-08-30 10:11:54
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help August 30th , 2024 Immunomodulatory Protein Derived from Parasites Enhances Regeneration in Mice Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here exploit an interesting source of immunomodulatory proteins , parasitic worms that live in the
Updated: 2024-08-29 17:25:20
Researchers are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that actually contributes to the problem.
Updated: 2024-08-29 17:24:18
Countries with greater inequalities -- whether economic, pollution or disease-based -- exhibited older brain ages.
Updated: 2024-08-29 10:22:25
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help August 29th , 2024 PGK1 is Rate-Limiting for ATP Production in Neurons Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Mitochondria must produce the chemical energy store molecule ATP in order for cells to function . The neurons lost in Parkinson's disease are
Updated: 2024-08-29 10:11:38
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help August 29th , 2024 The Relationship Between Physical Fitness and Biological Age Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Early epigenetic clocks were insensitive to physical fitness , which didn't make much sense given the evident relationship between
Updated: 2024-08-28 18:00:09
Some years after first coming to the conclusion that treating aging as a medical condition is possible, a great idea, something that should be supported by vastly more research and development funding than is actually the case, one starts to lose touch with how most people think about aging, medical research, and medicine. Which is to say that it is in the background, not thought about that much at all, and aging is taken for granted. Not a big problem, just the state of things. It is akin to all of those people who don't think much about cancer medicine until they develop a cancer, and even then treat the state of medical capabilities as set in stone, a fixed state of the world to […]
Updated: 2024-08-28 15:44:01
In-person contact helps lead to lower levels of loneliness in older people, but other ways of staying in touch, such as phoning, emailing or texting, are not as effective in lowering loneliness, a team of researchers found.
Updated: 2024-08-28 15:43:55
Public healthcare systems are fiscally burdened due to an aging population. So, governments must find a way to persuade citizens to pay more for health insurance. Now, researchers have examined whether informing people about their future self-benefits from the healthcare system could garner support for higher health insurance contributions. While this approach increased support from those unaware of fiscal risks, the effect disappeared once they became aware, offering significant implications for policymakers and governments.
Updated: 2024-08-28 15:43:53
Type 2 diabetes and prediabetes are associated with accelerated brain aging, according to a new study. The good news is that this may be counteracted by a healthy lifestyle.
Updated: 2024-08-28 15:43:50
Researchers assessed DNA methylation at 800,000 sites in the genome in blood samples collected from 900 people. The study includes extensive clinical information on participants, who all provided spinal fluid samples, which have been used for diagnosis and monitoring of Alzheimer's disease, because it is in direct contact with the brain. However, collecting the fluid is an invasive procedure, so the team investigated whether they could instead use blood samples, through analyzing blood epigenetic signatures that are associated with Alzheimer's disease biomarkers, as this would be cheaper and easier to collect in practice.
Updated: 2024-08-28 10:22:06
Researchers here argue that the fine details of how and when amyloid-β is cleared from the brain matters greatly in the treatment of Alzheimer's disease. To make the point they use a form of antigen-binding protein known as an anticalin, a technology that produces similar outcomes to monoclonal antibodies but with fewer inflammatory side-effects. The researchers target forms of amyloid-β that arise prior to the formation of amyloid plaques, attacking the very earliest stages leading to pathology. It works in a mouse model of Alzheimer's disease, but it is worth bearing in mind that these models are very artificial and a great deal of what has worked in mice has failed in humans. Until relatively recently, treatment strategies aiming at the scavenging of amyloid-β (Aβ) […]
Updated: 2024-08-28 10:11:59
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help August 28th , 2024 Senescent Cells in Aged Tissues May Use Immune Checkpoints to Prevent Immune Clearance Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Immune clearance of senescence cells falters with age becoming less efficient . This allows lingering
Updated: 2024-08-27 18:25:22
How much of academia and industry is headed in the wrong direction in the matter of treating aging as a medical condition, working on projects that are unlikely to produce meaningful extension of human life span? I am largely in agreement with the author of today's open access paper, at least to the point of saying that a large fraction of projects cannot and will not move the needle on human life span, and that likely includes near everything commonly grouped under the heading of geroscience. That means calorie restriction mimetics, autophagy upregulation, small molecules that improve mitophagy, and so forth. These largely pharmacological approaches are unified in their inability to improve on the effects of exercise, where tested in humans, with very few exceptions […]
Updated: 2024-08-26 22:29:23
Acute kidney injury is associated with an increased risk of developing dementia, according to a new study.
Updated: 2024-08-23 04:00:44
Dementia with Lewy bodies is a type of dementia that is similar to both Alzheimer's disease and Parkinson's disease but studies on long-term treatments are lacking. A new study highlights the potential cognitive benefits of cholinesterase inhibitor treatment.
Updated: 2024-08-22 18:26:47
A new study describes a link between inflammation caused by senescent cells and a protein that helps pack and unpack DNA.
Updated: 2024-08-21 04:41:54
Scientists investigating long COVID in youth found similar but distinguishable patterns between school-age children (ages 6-11 years) and adolescents (ages 12-17 years) and identified their most common symptoms.
Updated: 2024-08-19 17:07:19
Researchers have uncovered DNA markers associated with retroelements, remnants of ancient viral genetic material, in our genes that act as highly accurate epigenetic clocks predicting chronological age. The results support the idea that certain retroelements in the human genome may be involved in aging.
Updated: 2024-08-19 17:05:07
People with Down syndrome are likely to develop Alzheimer's disease at a young age, with autopsy studies showing that by age 40 years, the brains of individuals with Down syndrome have amyloid plaques. Yet people with Down syndrome have been excluded from or underrepresented in clinical trials of new therapies for treating AD.
Updated: 2024-08-14 20:07:30
People 60 and older with untreated high blood pressure may have an increased risk of Alzheimer's disease compared to both people who have been or are being treated for high blood pressure as well as people without the chronic condition. These results do not prove that untreated high blood pressure causes Alzheimer's disease, they only show an association.
Updated: 2024-08-14 20:06:55
Older age, female sex, irregular heart rhythms, and daily activity levels can help to predict how much Alzheimer's Disease patients' cognitive function will decline, and how much they will depend on their caregivers over the next two years. The results suggest new ways to predict cognitive decline in patients, and that caregivers need to be considered in treatment plans.
Updated: 2024-08-14 04:46:38
This new study found that an episode of shingles is associated with about a 20 percent higher long-term risk of subjective cognitive decline.
Updated: 2024-08-13 23:23:44
A new study comparing expected lifespans among six high-income English-speaking countries found that Australians live the longest while American lifespans faltered over the last three decades.
Updated: 2024-08-13 17:20:28
A new type of degenerative brain disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), was recognized just a decade or so ago, and remains relatively unknown. In the disease, the TDP-43 protein accumulates particularly in the limbic brain regions, which are also affected in the early stages of Alzheimer's disease. Accordingly, symptoms of LATE are similar to those of early Alzheimer's, but typically progress more slowly and are milder.
Updated: 2024-08-12 04:32:33
People with type 2 diabetes are at increased risk of Alzheimer's disease and other cognitive problems. A new study shows that the reason may be that people with type 2 diabetes have more difficulty getting rid of a protein that may cause the disease.
Updated: 2024-08-12 04:32:17
Scientists explain how the amyloid beta deposits long known to build up in the brains of Alzheimer's patients serve as a kind of scaffold for the accumulation of other proteins. Because many of these proteins have known signaling functions, their presence around the amyloid accumulations, known as plaques, could be the culprit causing brain cell damage rather than the amyloid itself.
Updated: 2024-08-08 15:52:17
Researchers say they now know that offspring are inheriting dysfunction in their mitochondria as a result of their parents' substance abuse. This dysfunction causes these individuals to show early signs of age-related disease when they're still considered young, usually in their 40s.
Updated: 2024-08-06 17:11:48
Everyone wants to live to a ripe old age, but no one wants to be decrepit. Now, researchers demonstrated a treatment that could lengthen life -- and vigor -- up to the very end. Gerontologists describe how a group of mice lived 9% longer when they received monthly treatments, walking faster and gripping objects with greater strength than untreated mice of the same age.
