Updated: 2024-05-31 18:09:43
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 31st , 2024 Reviewing the Effects of Intermittent Fasting on Cognitive Function in Later Life Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment A reduced calorie intake produces beneficial changes to metabolism promoting autophagy and cell maintenance ,
Updated: 2024-05-31 10:22:27
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 31st , 2024 Quantifying the Difference Made by a Healthy Lifestyle in Later Life Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment In this study , researchers assessed the effects of a healthy lifestyle on mortality in older people suffering from chronic
Updated: 2024-05-31 10:11:42
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 31st , 2024 Too Little is Being Done to Move the Needle on Cardiovascular Disease Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Given that cardiovascular disease is the largest cause of human mortality , and the present dominant strategy of lowering
Updated: 2024-05-30 18:55:15
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 30th , 2024 Why Does Oral Microbiome Diversity Correlate with Late Life Cognitive Function Permalink With Comments Permalink No Comments Posted by Reason Read 2 Comments Add a Comment As the authors of today's open access paper note , their study is not the first to find a correlation between the
Updated: 2024-05-30 10:22:40
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 30th , 2024 Cellular Senescence Disrupts Adrenal Gland Circadian Rhythm in Aging Mice Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment This research makes for interesting reading in the context of a recent paper discussing a mismatch between brain and body
Updated: 2024-05-30 10:15:22
A considerable amount of effort has gone into assessing the biochemical differences between old people and extremely old people, in search of protective mechanisms that might be used as a basis for therapies to modestly slow the pace of aging. This may not be the best approach from the point of view of size of effect achieved at the end of the day, as centenarians are still meaningfully impacted by aging, their physiology far removed from that of a young individual, but it is an approach well suited to the present environment of low cost omics technologies. Everything that can be measured attracts attention, and the cheaper the measure is to enact, the more that researchers will use it. Previous studies of the aging human […]
Updated: 2024-05-29 18:50:37
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 29th , 2024 Reviewing Amino Acid Restriction as an Approach to Slow Aging Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The practice of calorie restriction reducing calorie intake to as much as 40 below ad libitum intake while still maintaining optimal
Updated: 2024-05-29 18:40:17
The benefits gained with higher lifestyle scores may be associated with the positive influence of heart disease risk factors on the aging of the body and its cells, finds a new study in the Journal of the American Heart Association
Updated: 2024-05-29 10:22:15
Klotho is a longevity-associated protein. Studies in mice show that upregulation lengthens life, while downregulation shortens life. In humans, levels of the soluble circulating form of α-klotho correlate with many aspects of aging. More of it is better, less of it is worse. Here, researchers show this to be the case for inflammation related to osteoarthritis. Identification of the full panoply of mechanisms by which klotho acts to improve health remains a work in progress. It is predominantly active in the kidney, and is clearly protective of kidney health and function in later life. Kidney function is important to the rest of the body, and this may be enough to explain much of the effect on health, inflammation, life span, and so forth. Circulating α-klotho […]
Updated: 2024-05-29 10:09:03
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help May 29th , 2024 Oxidative Stress in Intervertebral Disc Degeneration Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Oxidative stress is the presence of a damaging level of oxidative molecules , more than cells can cope with without resulting in harmfully
Updated: 2024-05-28 18:21:10
Today's open access review paper goes back to the basics on aging and cancer, a first principles consideration of whether or not the evidence shows that we should think of cancer as a distinct process from aging. It is certainly the case that while cancer incidence increases with age, it doesn't keep on increasing ad infinitum. In very late life, 90 and older, those who are not already dead from one cause or another actually have lower rates of cancer than younger cohorts. This may not be a only matter of those most prone to cancer having died already, but also reflect something fundamental about the way in which cellular biochemistry changes at that age. The majority of cancer risk scales with age-related disability of […]
Updated: 2024-05-27 15:59:02
Researchers made a significant breakthrough in Alzheimer's disease research by identifying a novel way to potentially slow down or even halt disease progression. The study, which focuses on the role of reactive astrocytes and the plexin-B1 protein in Alzheimer's pathophysiology, provides crucial insights into brain cell communication and opens the door to innovative treatment strategies.
Updated: 2024-05-22 17:03:13
A substance naturally occurring in i.a. pomegranates, strawberries and walnuts can improve memory and treatment of Alzheimer's disease, a new study concludes.
Updated: 2024-05-21 04:43:23
A new study suggests better nutrition might help prevent cognitive decline. Working with a group of 100 cognitively healthy participants aged 65 to 75, a research team combined neuroscience with nutritional science to identify a specific nutrient profile linked with better performance on cognitive tests. Nutrient biomarkers identified via blood tests revealed a combination of fatty acids, antioxidants and carotenoids, and two forms of Vitamin E and choline -- very similar to the Mediterranean diet -- in the systems of those who showed slower than expected brain aging in MRI scans and cognitive assessments.
Updated: 2024-05-21 04:43:12
Researchers analyzed data from the Japan Gerontological Evaluation Study and found that socioeconomic status (SES) transitions affect dementia risk. Specifically, upward SES mobility is greater associated with reduced dementia risk and extended healthy aging with dementia-free lifespan, while downward mobility increases risk. The study of 9,186 participants found that lifestyle, comorbidities, and social factors mediate this relationship, highlighting the importance of SES in cognitive health and preventing dementia.
Updated: 2024-05-20 04:27:54
New research shows that ferroptosis, a form of cell death, occurs in severe COVID-19 patient lungs. Stopping it improves outcomes.
Updated: 2024-05-16 20:05:24
To date, approaches to treatments for Alzheimer's disease have not addressed the contribution of protein insolubility as a general phenomenon, instead focusing on one or two insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health.
Updated: 2024-05-14 18:14:05
New research identifies a larger pool of genes involved in clonal haematopoiesis than previously thought, and their implications for disease and diagnostic tests.
Updated: 2024-05-09 21:02:41
Discrimination may speed up the biological processes of aging, according to a new study.
Updated: 2024-05-09 15:07:40
Aging clocks can measure the biological age of humans with high precision. Biological age can be influenced by environmental factors such as smoking or diet, thus deviating from the chronological age that is calculated using the date of birth. The precision of these aging clocks suggests that the aging process follows a program. Scientists have now discovered that aging clocks actually measure the increase in stochastic changes in cells.
Updated: 2024-05-08 23:04:18
Researcher found that exposed individuals with confirmed TB infection -- i.e. a positive skin or blood test -- should receive priority treatment in settings with a low prevalence of the disease, regardless of their age. However, in high-burden settings, all exposed individuals should be considered for preventative treatment, even without a confirmed infection. This strategy can help end the tuberculosis epidemic and support global public health efforts to reduce TB mortality by 95 percent by 2035 (from 2015 estimates).
Updated: 2024-05-07 19:02:36
In people's early- to mid-20s, they reach what is called peak bone mineral density, which is higher for men than it is for women, according to researchers. This peak is one of the main determinants of fracture risk later in life. After reaching this peak, a person's bone density remains roughly stable for a couple of decades. Then, when women enter the menopausal transition, they experience accelerated bone loss. Men also experience bone density decline as they age. Sleep patterns also evolve over time.
