Updated: 2024-09-30 19:01:12
With the global population ageing rapidly, sarcopenia, a condition that affects millions of older adults and severely diminishes their quality of life, is emerging as an urgent public health issue. Scientists have now identified a protein that regulates cellular clean-up, could also hold the key to new treatments for age-related muscle loss and muscle wasting in cancer patients, enhancing quality of life.
Updated: 2024-09-30 19:01:12
A new resource allows for studies of human longevity and resilience that can fuel the discovery and validation of novel therapeutics for aging-related disease.
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With an aging population and fewer physicians available, the burden on rural communities is set to grow.
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A research team has successfully recreated the structure of wrinkles in biological tissue in vitro, uncovering the mechanisms behind their formation.
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People whose diet more closely resembles the MIND diet may have a lower risk of cognitive impairment, according to a new study. Results were similar for Black and white participants. These results do not prove that the MIND diet prevents cognitive impairment, they only show an association.
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A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.
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A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults.
Updated: 2024-09-30 19:01:12
Two new papers by a team of researchers demonstrate that evaluating microRNAs in blood can be used not only to diagnose mild cognitive impairment (MCI) but also, critically, to predict the conversion from MCI to dementia due to Alzheimer's disease. Moreover, the researchers uncovered microRNA candidate molecular biomarkers that associate with current Amyloid, Tau, and Neurodegeneration (A/T/N) Alzheimer's biomarkers.
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Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
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Scientists have discovered a novel way to lengthen the 'healthspan' of a women's ovaries -- improving maintenance of the ovaries and preventing key age-related changes in ovarian function. 'Healthspan' refers to the length of time a person remains healthy and free from serious illness or chronic diseases.
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Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.
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A new biomarker makes it easier to distinguish between Alzheimer's and primary tauopathy.
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Outdoor light at night could be a significant risk factor in Alzheimer's disease, according to new research from Rush.
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A study found that new monoclonal antibody drugs for Alzheimer's may slow cognitive impairment through boosting levels of a specific protein in the brain.
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The risk of skin cancer for adults under the age of 50 is now decreasing for the first time in Sweden.
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Findings from a new USC Dornsife study suggest that when older adults fall for financial scams, it could be an early warning sign of Alzheimer's disease. Researchers used MRI scans to find that older adults with thinner brain regions linked to memory and decision-making -- areas often affected early in Alzheimer's -- were more likely to be vulnerable to financial scams. The findings offer hope that financial vulnerability could be used as a simple screening tool to help identify early signs of cognitive decline, especially in people over 70.
Updated: 2024-09-30 19:01:12
A novel study addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults. In preclinical models, the research team found that anakinra, a drug typically used for inflammatory conditions such as rheumatoid arthritis, can be repurposed to block harmful signals between early lung cancer lesions and the bone marrow. This is critical, say the investigators, because as the immune system ages, it creates harmful inflammation that can drive cancer development.
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Research discovered a unique and promising avenue for diagnosing Alzheimer's disease (AD) earlier -- by analyzing AD biomarkers in blood -- so that the impacts of dementia can be reduced. The researchers applied inorganic analytical geochemistry techniques, originally developed for cosmochemistry -- for example, to study the formation and evolution of the Earth, the Moon, other planets and asteroid samples -- and adapted these highly sensitive techniques to search for early biomarkers of AD in human blood serum.
Updated: 2024-09-30 19:01:12
Sports-related concussions (SRC) may not be associated with long-term cognitive risks for non-professional athletes, a new study suggests. In fact, study participants who had experienced an SRC had better cognitive performance in some areas than those who had never suffered a concussion, pointing to potential protective effects of sports participation.
Updated: 2024-09-30 19:01:12
Researchers are using works by Johann Sebastian Bach, along with MEG and MRI scans, to investigate how the brain compensates for age-related changes.
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It turns out that a particular gene has a great influence on longevity, a new study concludes. This may pave the way for new treatment.
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Scientists have discovered that coordination between basic cellular processes is lost with increasing age.
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Aging is a major risk factor for neurodegenerative diseases, but the molecular mechanisms behind this relationship are not clear. In a recent study, researchers explored the role of PQBP3, a protein that helps stabilize the nuclear membrane, in cellular senescence and neurodegeneration. Their findings suggest that PQBP3 might be a promising therapeutic target for managing neurodegenerative diseases and the neuronal symptoms of aging.
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The lessons to take away from the fact that therapies for type 2 diabetes lower risk of age-related disease in diabetic patient populations are much the same as the lessons to take away from the fact that weight loss drugs produce a reduction in age-related disease. Firstly the diabetic metabolism is harmful to the degree that is remains poorly controlled, and secondly excess weight is harmful. These lessons may have little relevance to the aging of thin, physically fit people, and diabetes-associated metabolic processes may not be the most important area of focus when it comes to the aging of thin, physically fit people. The retrospective study looked at people with type 2 diabetes who started diabetes medication from 2014 to 2019 in South Korea. […]
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 30th , 2024 Molybdenum Disulfide Structures Increase Mitochondrial Biogenesis Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here report on initial in vitro studies of a novel approach to improve mitochondrial function via an increased
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 30th , 2024 Inflammatory Trigger STING is Found to Also Regulate Aspects of Lysosomal Function Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment One of the reasons why older people exhibit chronic inflammation is that innate immune pathways such as
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 27th , 2024 Evidence for APOEε4 to Speed Neurodegeneration by Altering Macrophage Function Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The primary function of the APOE protein is lipid transport appearing in many of the different forms of
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 26th , 2024 Enhancing Mitochondrial Function as a Way to Treat Neurodegenerative Conditions Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Every cell in the body contains hundreds of mitochondria their primary task the generation of chemical energy
Updated: 2024-09-30 19:01:11
Cellular metabolism is highly complex, but that complexity can be divided into functional modules that only interact with one another indirectly. Those indirect interactions do exist, however, and so loss of function in one module will tend to affect others. In this way aging is a process of countless distinct changes, but the effects of those changes are felt everywhere. Or so we might hypothesis, analogously to our experience that declining function in one organ (the kidney, say) will have negative effects on the function of all of the other organs in the body. That said, should we should expect aging to occur uniformly across distinct functional areas of cell biochemistry? Researchers here present data in support of the idea that the progression of aging […]
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 26th , 2024 Amyloid-β and Tau Cause Measurable Loss of Brain Function Prior to Evident Symptoms of Alzheimer's Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Evidence suggests that Alzheimer's disease develops slowly over time for potentially
Updated: 2024-09-30 19:01:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 26th , 2024 Advocating for Extracellular Vesicle Therapies to Treat Neurodegenerative Conditions Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment All cells secrete small membrane wrapped packages of molecules , known as extracellular vesicles How the
Updated: 2024-09-30 19:01:11
A good tissue model tends to speed up research to the degree that it is less costly and easier to manage than animal models. This is especially true of age-related conditions, as the animal models tend to require a supply of aged animals, which is relatively expensive in terms of time and cost when compared with maintaining a supply of young animals. It is a little early to say whether the model of wrinkle formation noted here is a good tissue model, whether it adequately replicates the mechanisms of wrinkle formation in real tissue. There is sufficient interest in skin aging to ensure that the model will be assessed rigorously in the years ahead, however. Despite the significance of biological wrinkle structures, much of the […]
