Updated: 2025-01-19 11:11:02
, Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 19th , 2025 Fight Aging Newsletter , January 20th 2025 Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Fight Aging publishes news and commentary relevant to the goal of ending all age-related disease , to be achieved by bringing the mechanisms of
Updated: 2025-01-17 19:19:17
One of the many reasons to think that chronic inflammation is an important aspect of degenerative aging is that extremely old individuals, those who have outlived more than 99% of their birth cohort, tend to exhibit levels of inflammation that are similar to those of younger adults. A number of studies of centenarians (100 years and older), semi-supercentenarians (105 years and older) and supercentenarians (110 years and older) have noted unusually low levels of inflammatory markers, typically lower than the inflammation normally seen in later life from 60 to 100 in the general population. This is not to say that being older than 100 is a walk in the park, as matters presently stand. These individuals approach a 50% yearly mortality rate, are frail, and […]
Updated: 2025-01-17 11:22:27
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 17th , 2025 Considering the Development of Senolytic Vaccines Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Senescent cells can in principle be distinguished by cell surface markers , and the immune system has evolved to detect and destroy these
Updated: 2025-01-17 11:11:07
The difference between the sexes in the matter of aging can be summarized crudely as being that women live longer but in worse physical condition than male survivors of an equivalent age. How and why this is the case is the subject of a great deal of research, but the research community has yet to reach a good conclusion on the biochemistry involved. Yet this may well be irrelevant to the future of therapies aimed at repairing the cell and tissue damage that causes aging, as that underlying damage is the same for both sexes. To the degree that medical science can produce rejuvenation, the details of how uncontrolled aging progresses differently in different people becomes a matter of curiosity only, not a priority. Men […]
Updated: 2025-01-17 05:34:53
A new study has found older-looking brains in adults with sickle cell disease, helping to explain the cognitive challenges experienced by such individuals. A brain image from a healthy individual (left) shows a larger brain with more white matter compared with a brain image from a patient with sickle cell disease (right). Healthy individuals experiencing economic deprivation also had more-aged appearing brains.
Updated: 2025-01-16 20:11:40
What can be found in a human blood sample that either correlates with or predicts exceptional healthspan or lifespan? Quite the variety of research efforts touch on this question, from the development of aging clocks to the construction of omics databases for blood and tissue samples taken from centenarians. People age as a result of the same underlying processes of damage and dysfunction, but the pace of aging clearly varies widely. It is generally accepted in the research community that efficient ways to measure the state of biological aging are needed in order to speed the development of therapies to treat aging. Without the ability to rapidly determine the effects of an alleged anti-aging therapy immediately after administration, the only recourse is to wait and […]
Updated: 2025-01-16 11:22:52
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 16th , 2025 Considering Mitochondrial Dysfunction as a Contributing Cause of Intervertebral Disc Degeneration Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here review the evidence for age-related loss of mitochondrial function to
Updated: 2025-01-16 11:11:43
In mice, senolytic therapies to clear senescent cells seem such a panacea for age-related conditions that it is always interesting to see evidence for an aspect of aging that is not helped by removal of a portion of the burden of lingering senescent cells. Here, researchers show that senolytics do nothing to help aged mice resist influenza infection if they are administered during or shortly before exposure. Based on what is known of the role of cellular senescence in aging, one would expect an aged mouse that has been treated once with senolytics to later be more resilient to stresses of all sorts, but it likely takes some time for the benefits to be realized, longer than was allowed for here. Aging is a major […]
Updated: 2025-01-16 04:07:49
Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research has found. The findings provide new hope in the battle against this devastating disorder.
Updated: 2025-01-15 21:48:28
People who eat more red meat, especially processed red meat like bacon, sausage and bologna, are more likely to have a higher risk of cognitive decline and dementia when compared to those who eat very little red meat, according to a new study.
Updated: 2025-01-15 18:48:31
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 15th , 2025 IL-23R as a Blood Biomarker of the Age-Related Burden of Senescent Cells Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Senescent cells are created constantly throughout life , largely as somatic cells reach the Hayflick limit on
Updated: 2025-01-15 11:21:59
Epigenetic clocks assess data derived from a bulk set of cells derived from tissues. This will be a mix of cells of different types and subpopulations, and thus some portion of age-related changes might be due to shifts in the relative numbers of these cell types. This has already been explored to some degree in the context of white blood cells in a blood sample, and the better commercial epigenetic age assays are now somewhat improved for that exploration. Here researchers discuss the problem more generally, and demonstrate that separating out cell types can be expected to improve epigenetic clocks and age assessment for any tissue. The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as […]
Updated: 2025-01-15 11:04:25
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 15th , 2025 The Lung Extracellular Matrix Shows Increased IsoDGR Modifications with Age Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Cells react to the state of the extracellular matrix that they reside in . Changes to the molecules of the
Updated: 2025-01-13 18:46:09
Researchers have uncovered novel insights into how brain function disruptions related to cerebrovascular disease (CeVD) interact with Alzheimer's disease (AD) pathology to impact neurodegeneration and cognition in older adults.
Updated: 2025-01-13 18:40:46
A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.
Updated: 2025-01-10 19:35:53
Cognitive profiles for early diagnosis of Dementia with Lewy bodies (DLB) have been outlined in a new study. Although DLB is the second most common neurodegenerative dementia following Alzheimer's Disease, it is usually misdiagnosed, preventing affected people from accessing care better tailored to their prognosis.
Updated: 2025-01-07 21:18:36
A study has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in individuals 90 and older.
Updated: 2025-01-06 03:07:28
A team has devised a more accurate way of measuring an indicator of kidney function known as glomerular filtration rate (GFR) by taking aging into account.
Updated: 2025-01-01 18:20:40
Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.
