Updated: 2023-09-29 19:22:04
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 29th , 2023 Valeric Acid as a Harmful Metabolite Generated by the Aged Gut Microbiome Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The balance of microbial populations making up the gut microbiome shifts with age . The research community has
Updated: 2023-09-29 10:22:49
The growing focus on cellular senescence as a contributing cause of aging has identified senescent cells as important agents in a range of conditions, age-related and otherwise. Interestingly, the pathology of both type 1 and type 2 diabetes appears to be mediated by senescent beta cells in the pancreas. Clearing senescent cells has been shown to be beneficial in animal models of these conditions, but it remains to be seen as to whether human patients will benefit. There are many conditions that might be treated with senolytic therapies to selectively destroy senescent cells, and only so many research groups and companies working in the space. Only a small number of age-related conditions are presently targeted by trials and programs of development, and forms of diabetes […]
Updated: 2023-09-29 10:11:56
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 29th , 2023 A Relationship Between the Gut Microbiome and Bone Density Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Changes in the gut microbiome take place with advancing age , an increase in populations that provoke chronic inflammation a
Updated: 2023-09-28 19:12:02
It is not too far from the truth to say that everyone in the field of aging research has their own theory of aging. Enormous amounts of data exists, measurements of near every aspect of cellular biochemistry, to note the ways in which these aspects change with age, yet we lack the framework to link all of the data together, to firmly state what is important and what is not, what is cause, what is consequence, and how exactly the network of age-related changes are linked to one another. Aging is a dark forest in which the boundaries are well mapped, but only a few of the interior features have been well explored. So why not a view of aging centered around hormesis? That is […]
Updated: 2023-09-28 10:22:06
Large mammals must evolve efficient ways to suppress cancer in order to become large. Being large means having more cells, any of which could undergo potentially cancerous mutations. In order for cetaceans such as the large whales to exist at all, they must employ much more effective anti-cancer strategies than those found in humans. If we can identify those strategies, then perhaps they might form the basis for novel cancer therapies. Given the state of this research, it is still too early to say whether this is a plausible near future opportunity, or whether it will turn out to require to great a degree of biological engineering to accomplish over the next few decades. Despite the generally increased cancer risk in large, long-lived organisms, cetaceans, […]
Updated: 2023-09-28 10:11:30
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 28th , 2023 CD44 in the Aging of the Vascular Endothelium Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Comparing this paper with a recent examination of CD44 in species life span differences is a good illustration of the complexity of cellular
Updated: 2023-09-27 19:04:28
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 27th , 2023 Senescent Microglia Harm the Brain via Lactate Generation Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment A sizable body of evidence supports a role for inflammatory microglia in the aging of the brain . Microglia are innate immune cells
Updated: 2023-09-27 10:22:31
One of the areas of research that seems constantly on the verge of producing an impressive advance is the use of nanoscale scaffold materials to encourage regrowth of tissue, such as bone and cartilage. The space of possible combinations of techniques is vast, and there only so many researchers, and only so much funding. Advances such as the one noted here are published by research groups several times a year, and this has been the case for more than a decade now. This part of the field seems eternally in a state of progress and exploration, with promising leads, yet it remains the case that clinical options for regenerative medicine are far more limited than the space of the possible demonstrated in animal studies. Osteochondral […]
Updated: 2023-09-27 10:12:05
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help September 27th , 2023 A Paper on the Cyclarity Approach to Binding 7-Ketocholesterol Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment While cholesterol is essential to health , localized excesses of cholesterol produce toxicity and cell dysfunction . Normal
Updated: 2023-09-26 19:11:07
Epigenetic marks on the genome, such as DNA methylation at CpG sites, determine its structure. That in turn determines which regions of DNA are exposed to transcriptional machinery, which proteins are manufactured, and thus the behavior of the cell. Epigenetic marks and the structure of the genome change constantly in response to circumstances, but some of these changes have been found to be characteristic of aging, leading to the development of epigenetic clocks to measure biological age. In today's open access paper, the authors report on a novel approach to the development of a clock that measures the burden of aging. Rather than using unbiased machine learning across as many DNA methylation sites on the genome as can be usefully measured, the researchers consider only […]
Updated: 2023-09-18 20:31:59
A telecare program that improves outcomes for patients with dementia and lightens the load for unpaid caregivers also has the surprising bonus of cutting Medicare costs, according to new research.
Updated: 2023-09-11 19:11:43
A new survey of an under-explored aspect of human biology uncovers the many roles of the body's 'greasy molecules.'
Updated: 2023-09-08 05:59:47
Medical researchers have used a 3D human neural cell culture model to show that the exercise-induced muscle hormone, irisin, reduces the level of amyloid beta deposits associated with Alzheimer's disease.
Updated: 2023-09-07 18:03:37
Scientists are reporting results from a Phase I trial in an area of promising research for Alzheimer's disease -- cellular senescence.
Updated: 2023-09-06 21:18:15
A study of twins shows that having a concussion early in life is tied to having lower scores on tests of thinking and memory skills decades later as well as having more rapid decline in those scores than twins who did not have a concussion, or traumatic brain injury (TBI).
Updated: 2023-09-06 16:24:12
Neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmosets to accelerate the pace of drug discovery and rebuild the foundation for future translational studies.
Updated: 2023-09-06 16:23:54
Although about half of people go through menopause, less than 15% of them receive effective treatment for their symptoms. Treatment options for people experiencing irritating or severe menopause symptoms are often under researched, and some have questionable efficacy, or cause harmful side effects. Menopause experts now summarize what we know about menopause, call for more research into the timeline and treatment of menopause, and encourage individualized, holistic treatment that addresses both menopausal symptoms and other systemic changes happening in the body.
