Updated: 2023-04-28 18:28:32
The article I'll point out today touches on an important point regarding present efforts to develop therapies capable of slowing or reversing the progression of aging. Some of those therapies manipulate metabolism in ways that are known to modestly slow aging, such as upregulation of autophagy via mTOR inhibition, but the full holistic understanding of how they work is as yet lacking. Others target specific causative mechanisms of aging, such as the accumulation of senescent cells and their disruptive senescence-associated secretory phenotype. There, we lack the full picture of how the well-understood cause contributes in detail to the very complex changes of later stage aging, but we can at least be fairly certain that when we see benefits in older animals and people, we know […]
Updated: 2023-04-28 10:22:34
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 28th , 2023 Targeting an Imbalance of Inflammatory Factors Induces Regeneration in Osteoarthritic Joints Permalink Read 2 Comments Add a Comment Posted by Reason Researchers here demonstrate that various cell populations found in osteoarthritic joint tissue remain competent and capable of
Updated: 2023-04-28 10:14:43
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 28th , 2023 Current Aging Clocks are Arguably Too Sensitive to Transient Stresses Permalink No Comments Yet Add a Comment Posted by Reason Numerous clocks to assess biological age have been constructed based on comparisons of epigenetic transcriptomic proteomic and other data that changes with age
Updated: 2023-04-27 19:22:56
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains meaningfully beneficial factors missing in old plasma, and mixed to poor results suggest that either this hypothesis is untrue, or that plasma transfer is not delivering enough of those beneficial factors. That said, today's open access preprint paper is an example of a plasma transfer study that did manage to produce benefits in old rats. One might well ask what exactly about the experimental procedure is the important difference when compared with earlier exercises. That the treatment was carried out biweekly for the entire remaining life span of the old rats […]
Updated: 2023-04-27 10:22:32
Evolution tends towards reuse of component parts, and as a result no gene has just one function. Telomerase in particular is involved in far more than just extending telomeres, the caps that the ends of chromosomes that are reduced with each cell division. In humans, stem cells express telomerase to maintain long telomeres, while all other cells can replicate only a limited number of times. What are the other functions of telomerase? As first noted some years ago, telomerase may be protective of mitochondrial function, and the paper here lists a few other interesting line items as well: angiogenesis, metabolism, regulation of gene expression, and so forth. When we see evidence for a large upregulation of telomerase expression achieved via gene therapy to extend life […]
Updated: 2023-04-27 10:11:47
The first epigenetic clocks used to assess biological age were, oddly, insensitive to the state of physical fitness. This is not an intuitive outcome, given that we know lifestyle choices relating to fitness appear have measurable effects on human life expectancy in epidemiological studies. This is one of a number of hints that suggest that most clocks are incomplete, that they only reflect some fraction of the many factors affecting health and mortality. Researchers here instead use a transcriptomic clock to assess the effects of a high intensity exercise program, and do see an effect that looks more reasonable when compared to the results of epidemiological studies of exercise and fitness. This is one small step of many that will need to be taken to […]
Updated: 2023-04-26 19:11:40
, Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 26th , 2023 More Age-Related Conditions , Greater Risk of Frailty Permalink No Comments Yet Add a Comment Posted by Reason The many varied types of age-related condition emerge from the effects of a much smaller set of underlying processes of aging . People age at different rates , largely the
Updated: 2023-04-26 10:22:41
Use of electromagnetic fields to influence cell behavior is understudied in comparison to the use of small molecules. Researchers here offer an example of a potential use for this class of approach to therapy in wound healing, working in models of skin tissue. Tissue models are not tissue, but nonetheless, it is interesting to look at this work in the context of the few other studies suggesting that regeneration can be accelerated by the suitable application of electric currents and electromagnetic fields. The researchers worked from an old hypothesis that electric stimulation of damaged skin can be used to heal wounds. The idea is that skin cells are electrotactic, which means that they directionally 'migrate' in electric fields. This means that if an electric field […]
Updated: 2023-04-26 10:11:21
, Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 26th , 2023 KDM5C Inhibition Reduces Osteoclast Activity , Increasing Bone Density Permalink No Comments Yet Add a Comment Posted by Reason Bone tissue is constantly remodeled through the activity of osteoblast cells , depositing extracellular matrix and osteoclast cells , breaking down
Updated: 2023-04-26 01:53:26
Scientists found that blood markers of two saturated fatty acids along with certain omega-6, -7 and -9 fatty acids correlated with better scores on tests of memory and were associated with larger brain structures in the frontal, temporal, parietal and insular cortices.
Updated: 2023-04-25 16:12:15
A new trial has found a new genetic therapy for Alzheimer's disease that is able to safely and successfully lower levels of the harmful tau protein known to cause the disease.
Updated: 2023-04-21 16:26:48
The biological age of humans and mice undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress, according to a new study. These changes occur over relatively short time periods of days or months, according to multiple independent epigenetic aging clocks.
Updated: 2023-04-20 16:01:28
Two doses of an FDA-approved sleeping pill reduced levels of Alzheimer's proteins in a small study of healthy volunteers. The study hints at the potential of sleep medications to slow or stop the progression of Alzheimer's disease, although much more work needs to be done to confirm the viability of such an approach.
Updated: 2023-04-20 13:07:24
Scientists hope the new tool could be used to make it easier for GPs and patients to get information on dementia risk factors.
Updated: 2023-04-20 01:19:36
In people with no thinking and memory problems, a simple test may predict the risk of developing cognitive impairment years later, according to a new study.
Updated: 2023-04-12 18:12:19
Scientists found mitochondria size does not coincide with energy demand in the brain as it ages, potentially causing age-related working memory impairment. Their findings point to mitochondria dysfunction rather than synapse loss as cause for age-related cognitive impairment, illuminating research on aging and age-related illness, like Alzheimer's.
Updated: 2023-04-12 18:11:58
Early diagnosis and treatment of Alzheimer's disease requires reliable and cost-effective screening methods. Researchers have now discovered that a type of sugar molecule in blood is associated with the level of tau, a protein that plays a critical role in the development of severe dementia. The study can pave the way for a simple screening procedure able to predict onset ten years in advance.
Updated: 2023-04-12 18:11:16
A new study has found that older persons with mild cognitive impairment (MCI), a common type of memory loss, were 30% more likely to regain normal cognition if they had taken in positive beliefs about aging from their culture, compared to those who had taken in negative beliefs. Researchers also found that these positive beliefs also enabled participants to recover their cognition up to two years earlier than those with negative age beliefs. This cognitive recovery advantage was found regardless of baseline MCI severity.
Updated: 2023-04-12 18:11:07
Scientists have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers. With dietary restrictions, these processes could be reversed.
Updated: 2023-04-11 20:05:10
Among Indigenous, rural non-industrial populations inhabiting the tropical forests of lowland Bolivia, researchers report, there appears to be an optimal balance between levels of food consumption and exercise that maximizes healthy brain aging and reduces the risk of disease.
Updated: 2023-04-07 16:07:28
High blood pressure in early adulthood is associated with worse brain health in late life, according to a new study. Men, compared to women, may be more vulnerable to the detrimental effects of high blood pressure on the brain for some brain regions.
Updated: 2023-04-06 12:56:57
Researchers used a computer simulation model to show that the four dementia-care interventions saved between $2,800 and $13,000 in societal costs, depending on the type of intervention, and all reduced nursing home admissions and improved quality of life compared to usual care.
Updated: 2023-04-06 02:48:49
Researchers found childhood cancer survivors have higher mortality than the public, but survivors with a healthy lifestyle and fewer heart disease risk factors had lower risk.
Updated: 2023-04-04 16:42:39
Researchers have long known that many animals live longer in colder climates than in warmer climates. New research in C. elegans nematode worms suggests that this phenomenon is tied to a protein found in the nervous system that controls the expression of collagens, the primary building block of skin, bone and connective tissue in many animals. Since the C. elegans' protein is similar to nervous system receptor proteins found in other species including humans, the discovery potentially brings scientists closer to finding ways to harness collagen expression to slow down human aging and increase lifespan in the midst of global warming.
Updated: 2023-04-03 21:26:27
Women are more likely than men to develop Alzheimer's disease (AD), with women making up two-thirds of the population living with AD. A new study sheds light on the relationship between the risk of Alzheimer's disease and age of menopause and use of hormone therapy (HT).
Updated: 2023-04-03 18:34:49
A lower body temperature is one of the most effective mechanisms to prolong the lifespan of animals. New research has now described precisely how this works. The scientists show that cold can prevent the pathological aggregation of proteins typical for two aging-associated neurodegenerative diseases.
