Updated: 2023-07-31 19:16:13
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 31st , 2023 Examining the Details of Mitochondrial Dysfunction in the Aging Mouse Heart Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Every cell contains hundreds of mitochondria hard at work to produce the chemical energy store molecule adenosine
Updated: 2023-07-31 10:22:04
A few different approaches have been proposed to clear advanced glycation endproducts (AGEs) from the lens of the eye, where they build up with age to make the lens stiffer. That stiffness results from cross-linking of extracellular matrix molecules by AGEs, restricting their ability to move relative to one another, and thus changing the structural properties of thetissue. That in turn leads to presbyopia as the muscles of the eye can no longer produce the desired changes to the lens needed to focus on near objects. Sadly, the most advanced program of cross-link breaking for the eye, a formulation of lipoic acid choline ester, failed in its phase IIb clinical trial after promising earlier results. We might hope that other, similar approaches to lens cross-linking […]
Updated: 2023-07-31 10:11:07
Researchers here report on a large study showing that an increased risk of dementia is correlated with postmenopausal hormone treatment in women. It may well be the case that the people who opt into this form of treatment are doing so because they tend to be more burdened by the processes of aging, and are thus more likely to develop later dementia regardless of the therapy. Under the hood, a range of possibly relevant mechanisms can be used to argue for protective or harmful effects of increased levels of the hormones used in these therapies; the biochemistry is complex and there is a lack satisfactory answers as to whether long term use is in fact harmful in this way. Dementia affects more women than men […]
Updated: 2023-07-28 19:10:05
The Impetus Grants project has for the past few years aimed to make rapid, low-overhead philanthropic grants to researchers in order to accelerate aging research. While choosing to funding specific proposals, the organizers appear to keep the bigger picture in mind. One might not agree with their chosen directions, but they do try to support work that would otherwise not be supported. The recent call for submissions for the August 2023 $10 million round of grants starts out on a contrarian note, in search of projects that can stress test existing directions and theories in the field, and ends with a thought on accelerating translation of preclinical programs into animal studies. For my part, I'd say that the best approach to accelerate the field is […]
Updated: 2023-07-28 16:34:14
New Alzheimer's research suggests that enhanced light sensitivity may contribute to 'sundowning' -- the worsening of symptoms late in the day -- and spur sleep disruptions that contribute to the disease's progression.
Updated: 2023-07-28 10:22:36
A sizable body of evidence indicates that raised blood pressure correlates with increased mortality. There are good reasons for this relationship to exist. Excessive blood pressure damages small vessels and delicate tissues in organs throughout the body, and that damage adds up. It also contributes to harmful remodeling of the heart, making it larger and weaker, and accelerates the growth of atherosclerotic plaque in arterial walls. Excessively low blood pressure in later life is also indicative of conditions that tend to lead to raised mortality, of course. As this study shows, there is a safest range somewhere in the middle. We aimed to determine survival probabilities to age 90 for various systolic blood pressure (SBP) levels among women aged ≥ 65 years with or without […]
Updated: 2023-07-28 10:11:50
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 28th , 2023 Young Glial Progenitor Cells Outcompete Diseased Glial Cells in the Brain Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Researchers here report on a demonstration of glial cell competition in the brain , conducted in mice but using human
Updated: 2023-07-27 19:42:30
A gene encoding a protein linked to tau production -- tripartite motif protein 11 (TRIM11) -- was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer's disease (AD), while improving cognitive and motor abilities, according to new research.
Updated: 2023-07-27 19:11:03
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 27th , 2023 The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year . This
Updated: 2023-07-27 10:22:42
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 27th , 2023 The Extracellular Matrix in the Age-Related Impairment of Angiogenesis Permalink With Comments Permalink No Comments Posted by Reason Read 2 Comments Add a Comment The density of capillary networks declines with aging the result of a progressive impairment of the complex process of
Updated: 2023-07-27 10:04:12
Researchers here demonstrate that one can create a signature of replication-based epigenetic change in cells, and that this signature is stronger in old tissues and cancerous tissues. This leads to a view in which increased replication stress on cells in a tissue, meaning a tissue that is made up of cells that have divided more times on average, have shorter telomeres, and are closer to the Hayflick limit, creates an environment that is epigenetically predisposed towards cancer. Looking at this another way, aging is characterized by reduced stem cell function, meaning a lower pace of creation of daughter somatic cells to replace losses in a tissue. It seems inevitable that this must lead to a tissue in which the average somatic cell has replicated a […]
Updated: 2023-07-26 22:12:40
People who carry the gene variant associated with the strongest risk for Alzheimer's disease may lose their ability to detect odors earlier than people who do not carry the gene variant, which may be an early sign of future memory and thinking problems. The gene variant associated with this increased risk of Alzheimer's is called APOE e4.
Updated: 2023-07-26 18:42:30
The lifespan of a small roundworm that has been used as a key model organism in aging research is limited by how it self-sacrifices to feed its young, finds a new study.
Updated: 2023-07-26 16:30:16
Hospitalized older people who do not follow a Mediterranean diet could benefit from a physical exercise program to prevent hospitalization-associated disability, that is, loss of skills in daily-life activities. Therefore, if the factor of following a Mediterranean diet is included among the variables assessed on the hospital admission of elderly patients, more precise and personalized strategies could be designed to prevent hospitalization-associated disability, which is only frequent in the elderly.
Updated: 2023-07-25 22:19:14
Scientists have discovered what they believe to be the central mechanism behind cognitive decline associated with normal aging.
Updated: 2023-07-25 05:31:06
You might not think of diabetes when you think of muscle function. But a common diabetes drug that regulates blood sugar can also prevent muscle atrophy and muscular fibrosis -- which can help the elderly bounce back faster from injury or illness.
Updated: 2023-07-25 05:30:17
Researchers have identified a key trigger for 'inflammaging' -- inflammation that drives aging -- and that discovery could let us live longer, healthier lives.
Updated: 2023-07-24 05:25:16
A gene called Myc (pronounced 'mick') that is among the most important drivers of cancer in both mice and humans also plays a newly discovered crucial role in aging.
Updated: 2023-07-20 05:49:58
Volunteering in late life is associated with better cognitive function -- specifically, better executive function and episodic memory.
Updated: 2023-07-20 05:49:34
The majority of older adults with cognitive impairment are still driving, despite concerns raised by caregivers and others, a study finds. Researchers say it's best for caregivers to start conversations surrounding driving earlier while the care recipient is able to understand and actively participate in the discussion.
Updated: 2023-07-19 16:26:21
Women diagnosed and treated for breast cancer have increased biological aging compared to women who remain free of breast cancer, according to a new study. Among women diagnosed with breast cancer, the association with faster biological aging was most pronounced for those who received radiation therapy, while surgery showed no association with biological aging. This finding suggests that developing cancer is not what increases the aging effect.
Updated: 2023-07-18 15:57:22
Researchers have found an anti-aging function in a protein deep within human cells. Researchers have discovered that a protein called ATSF-1 controls a fine balance between the creation of new mitochondria and the repair of damaged mitochondria.
Updated: 2023-07-17 16:57:23
Common bone density scans can detect a predictor of cardiovascular health risk -- a process which can now be done a LOT faster.
Updated: 2023-07-12 05:47:40
An overdosed gene on chromosome 21 causes people with Down's Syndrome to age faster than the general population.
Updated: 2023-07-10 16:38:57
: Your source for the latest research news : Follow Facebook Twitter LinkedIn : Subscribe RSS Feeds advertisement Science News from research organizations 1 2 First bioavailable compound that specifically inhibits free radical production in mitochondria prevents and treats metabolic syndrome in mice A potential therapeutic for one of the major chronic diseases of aging : Date July 10, 2023 : Source Buck Institute for Research on Aging : Summary The free radical theory of aging is back in play after falling out of favor decades ago . Remember when people were taking massive doses of various vitamins and minerals Mopping up free radicals with antioxidants compromised beneficial metabolic signaling pathways leading to bad side effects What brings the theory back Researchers at the Buck
Updated: 2023-07-10 16:38:11
The findings could benefit efforts to develop new ways to treat and prevent hearing loss, including age-related hearing loss.
Updated: 2023-07-05 22:11:04
Older people who have fluctuating levels of cholesterol and triglycerides may have a higher risk of Alzheimer's disease and related dementias compared to people who have steady levels, according to new research. While the study found a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia.
