Updated: 2024-01-31 19:30:47
Atherosclerosis is the buildup of fatty plaques in the walls of blood vessels, impeding blood flow and eventually rupturing to produce a heart attack or stroke. It is the single largest cause of human mortality. Atherosclerosis is in part an inflammatory condition, accelerated by the state of chronic inflammation that arises in later life. In this context, levels of CCL17 have been shown to rise with age, while inhibition of CCL17 has been shown to reduce chronic inflammation and slow the progression of atherosclerosis. This outcome is achieved via effects on T cell behavior; CCL17 is expressed on the surface of dendritic cells and interacts with CCR4 on the surface of T cells. In doing so it represses the anti-inflammatory activity of regulatory T cells. […]
Updated: 2024-01-31 11:22:29
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped with. This approach has been used with great success to treat cancers, and may also see some use in the clearance of senescent cells provided that the cost is somehow greatly reduced. At present it is a very expensive therapeutic modality, given that a patient's cells must be extracted, genetically engineered, cultured for weeks or more to expand their numbers, and then reintroduced into the patient. The use of universal cells may allow a more efficient therapy, but a gene therapy that […]
Updated: 2024-01-31 11:11:04
Any sufficiently large set of biological data can be used to produce clocks that measure biological age, where a clock is some weighted combination of measurements that produces age as an output. At this point novel clocks are much less interesting than standardizing on one clock and working towards a better understanding of how exactly the clock measurements relate to underlying processes of aging. Without that understanding it is impossible to use clock assessments of biological age to accelerate research and development of therapies to treat aging as a medical condition. One has to know that they clock does in fact correctly assess the burden of damage that is targeted specifically by the therapy, whether it is senescent cells, or mitochondrial dysfunction, or any of […]
Updated: 2024-01-30 11:22:22
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 30th , 2024 Measuring Myelin Loss in the Aging Brain Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Myelin acts as an insulating sheath for the axonal connections that exist between neurons and is necessary for the correct function of these
Updated: 2024-01-30 11:11:29
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 30th , 2024 The Prospects for Treating Neurodegenerative Conditions by Modifying the Gut Microbiome Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment The gut microbiome interacts with the body via a wide range of mechanisms , including induction of
Updated: 2024-01-29 19:50:15
, , Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 29th , 2024 Interactions Between Innervation , Vascular Aging , and Loss of Capillary Density in the Heart Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment One noted aspect of vascular aging is that the processes of angiogenesis become less
Updated: 2024-01-29 11:22:37
The vascular system responds favorably to exercise at any age. A large portion of the benefits of exercise derive from improvements to vascular function throughout the body, and physical fitness can be maintained further into old age than most people believe to be the case. The flip side of this point is that a sizable fraction of the declines of later life are a matter of disuse, people living a more sedentary life than is optimal for the health and function of muscles, heart, and brain. These the most energy-hungry tissues and those that see the worst outcomes from a decline in vascular function and consequently reduced delivery of nutrients and oxygen. Beyond the matter of blood supply, exercise is also protective against mechanisms involved […]
Updated: 2024-01-29 11:11:49
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 29th , 2024 Modest Effects on Cognitive Decline from Multivitamin Use Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Setting aside cases of vitamin deficiency , the consensus on supplement use including vitamins in essentially healthy individuals is
Updated: 2024-01-29 05:24:59
Five cases of Alzheimer's disease are believed to have arisen as a result of medical treatments decades earlier, reports a team researchers.
Updated: 2024-01-29 05:24:15
Engaging in music throughout your life is associated with better brain health in older age, according to a new study. Scientists working on PROTECT, an online study open to people aged 40 and over, reviewed data from more than a thousand adults over the age of 40 to see the effect of playing a musical instrument -- or singing in a choir -- on brain health.
Updated: 2024-01-25 20:00:35
Middle-aged women who are exposed to toxic metals may have fewer eggs in their ovaries as they approach menopause, according to new research.
Updated: 2024-01-24 18:28:47
Scientists have found a way to reprogram T cells to fight aging. After using them to eliminate specific cells in mice, the scientists discovered they lived healthier lives and didn't develop aging-associated conditions like obesity and diabetes. Just one dose provided young mice with lifelong benefits and rejuvenated older mice.
Updated: 2024-01-22 05:00:17
Researchers discover biomarker that could indicate dementia much earlier than its onset.
Updated: 2024-01-18 05:21:10
Researchers tested the effects of a daily multivitamin on cognitive changes in a study of 573 participants with in-person visits in the COSMOS trial. The researchers also conducted a meta-analysis among over 5,000 non-overlapping participants across the three separate cognition studies within the COSMOS trial. Results showed a statistically significant benefit for cognition among participants taking the multi-vitamin compared to placebo, suggesting that a multi-vitamin could help prevent memory loss and slow cognitive aging among older adults.
Updated: 2024-01-15 01:20:25
Having more frequent urinary incontinence and leakage amounts is associated with higher odds of disability, according to researchers.
Updated: 2024-01-12 16:47:54
Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.
Updated: 2024-01-11 21:26:25
Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.
Updated: 2024-01-11 16:31:22
Recent findings have identified a potential new link to signs of skin aging -- the skin microbiome, the collection of microorganisms that inhabits our skin.
Updated: 2024-01-09 05:11:57
More than 65,000 men fall ill with prostate cancer each year in Germany. Twelve thousand of them develop a treatment-resistant form which eventually ends in death. Now, a team of researchers has developed an active substance that might in future represent a new treatment option. This substance, known as KMI169, targets an enzyme that plays an important role in the development of prostate cancer.
Updated: 2024-01-05 19:51:14
In a new study featuring data from 573,088 people, researchers have found a link between hearing loss and the development of dementia. The study is the largest of its kind to date.
Updated: 2024-01-04 05:27:56
A new study shows that adults with hearing loss who regularly used hearing aids had a 24% lower risk of mortality than those who never wore them.
Updated: 2024-01-04 05:20:02
Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. Scientists have now uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins -- and ultimately affect aging.
