Updated: 2024-03-29 18:22:54
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 29th , 2024 Problematic B Cells Accumulate in Visceral Fat and Indirectly Provoke Inflammation Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The authors of today's open access paper present an interesting and novel way in which visceral fat tissue
Updated: 2024-03-29 10:22:43
Researchers here report that life-long tristetraprolin (TTP) upregulation leads to reduced frailty and improved bone mineral density in aged mice. One of the functions of TTP is that it suppresses expression of the pro-inflammatory TNF-α cytokine, so a reduced degree of age-related inflammation would be the first place to look for an explanation of the outcome noted here. It is an open question as to whether TTP upregulation produces a more nuanced and reactive reduction of TNF-α signaling than is the case for the blunt, across the board inhibition achieved by present anti-TNF-α therapies, and is thus a mechanism that interferes less in the necessary immune response to injury and infection. Researchers have presented results from a study aiming to use a novel transgenic mouse […]
Updated: 2024-03-29 10:11:19
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 29th , 2024 Regulatory T Cells Contribute to Reduced Myelination in the Aging Brain Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Myelin surrounds the axons that connect neurons to one another , and is required for the transmission of electrical
Updated: 2024-03-28 19:19:49
It is evident and settled that stochastic nuclear DNA damage contributes to cancer. The more of it that you have, the worse your risk. What is still very much debated is whether nuclear DNA damage contributes meaningfully to degenerative aging, and how it does so. Most mutational damage to DNA occurs in regions that are inactive, in cells that have comparatively few divisions remaining before reaching the Hayflick limit. Even if damage alters the function of such a cell, in some non-cancerous way, it is unclear as to how this could amount to a meaningful contribution to loss of tissue function. The one school of thought is focused on somatic mosaicism, the spread of mutations throughout a tissue when mutational damage occurs in stem cells. […]
Updated: 2024-03-28 16:10:45
Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease -- and at an accelerated rate.
Updated: 2024-03-28 10:22:10
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 28th , 2024 Further Considering the Altered Transcription of Longer Genes with Age Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The machinery of gene expression changes with age . In recent years , it has been noted that the length of gene sequences
Updated: 2024-03-28 10:05:12
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 28th , 2024 Inhibiting P16 in Microglia Reduces Amyloid Plaques in Mice Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here show that targeting microglia in a mouse model of Alzheimer's disease to suppress p16 expression can reduce amyloid-β
Updated: 2024-03-27 18:48:12
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 27th , 2024 Loss of Anti-Microbial Peptides as a Mechanism for Age-Related Changes in Gut Microbiome Composition Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The balance of microbial populations making up the gut microbiome changes with age in ways
Updated: 2024-03-27 10:22:43
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 27th , 2024 Lipid Droplets in Microglia Involved in Alzheimer's Pathology Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Microglia are innate immune cells resident in the central nervous system Microglial dysfunction is clearly a contributing factor in
Updated: 2024-03-27 10:11:40
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help March 27th , 2024 More Commentary on the Role of PF4 in Reducing Brain Inflammation Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Platelets in the blood are not just involved in clotting . Near every aspect of our biology has evolved many different functions
Updated: 2024-03-27 05:47:03
Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.
Updated: 2024-03-27 05:46:15
Researchers say they have discovered that the protein puromycin-sensitive aminopeptidase (NPEPPS) plays a role in regulating response to platinum chemotherapy in patients with bladder cancer.
Updated: 2024-03-26 22:00:55
Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.
Updated: 2024-03-26 15:39:10
Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study. In the study, almost one in ten of over 50-year-olds were found to have tissue markers of Lewy body disease in the brain.
Updated: 2024-03-22 19:55:02
For the neurons in the brain to work smoothly and be able to process information, the central nervous system needs a strictly regulated environment. This is maintained by the blood-brain barrier, whereby specialized brain endothelial cells lining the inner walls of blood vessels regulate the exchange of molecules between the circulatory and nervous systems. Earlier studies have shown that various functions that are dependent on these cells, such as the integrity of the blood-brain barrier or the regulation of blood supply to the brain, decline over the course of a person's life. This dysregulation leads to a dysfunction of the brain vasculature and is therefore a major contributor to medical conditions such as strokes and dementia.
Updated: 2024-03-21 20:54:56
A new study has identified 17 genetic variants that may influence Alzheimer's disease risk, putting researchers one step closer to uncovering biological pathways to target for future treatment and prevention.
Updated: 2024-03-21 20:53:52
Aging may be less about specific 'aging genes' and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction.
Updated: 2024-03-20 05:25:12
A new study shows the keto diet prevents early memory decline in mice. A molecule in the diet plays a key role in slowing Alzheimer's disease.
Updated: 2024-03-19 05:29:32
The middle-aged brain could provide a window into future cognitive health. A team reviewed evidence from human and animal studies suggesting that middle age -- commonly considered as the period between 40 and 60 or 65 years of age -- marks a shift in brain aging. They argue that more research should be dedicated to middle age, a period of life that is historically understudied.
Updated: 2024-03-14 05:21:23
A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological mechanism of this protection was not well understood.
Updated: 2024-03-08 19:27:46
Researchers have uncovered blood-based markers linked with healthy and rapid aging, allowing them to predict a person's biological age -- how fast a person's cells and organs age regardless of their birth date.
Updated: 2024-03-06 20:04:50
Certain factors associated with developing age-related hearing loss differ by sex, including weight, smoking behavior, and hormone exposure, according to a new study.
