• A Decline in Stemness in Many Human Stem Cell Populations with Aging

    Updated: 2024-04-22 19:01:33
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 22nd , 2024 A Decline in Stemness in Many Human Stem Cell Populations with Aging Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Like the accumulation of senescent cells loss of stem cell function is a problematic feature of aging . Also like the

  • Exercise, Stress, and Cardiovascular Risk

    Updated: 2024-04-22 10:22:44
    , , Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 22nd , 2024 Exercise , Stress , and Cardiovascular Risk Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Exercise is well known to correlate with reduced risk of cardiovascular disease in human epidemiological studies . In animal studies , it is

  • Assessing Age-Related Changes in Muscle Stem Cell Biochemistry

    Updated: 2024-04-22 10:11:09
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 22nd , 2024 Assessing Age-Related Changes in Muscle Stem Cell Biochemistry Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Researchers here discuss some of the results achieved in building the Human Skeletal Muscle Aging Atlas Focusing on stem cells in

  • Fight Aging! Newsletter, April 22nd 2024

    Updated: 2024-04-21 10:25:01
    , Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 21st , 2024 Fight Aging Newsletter , April 22nd 2024 Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Fight Aging publishes news and commentary relevant to the goal of ending all age-related disease , to be achieved by bringing the mechanisms of aging

  • Parkinson's Disease in the SENS View of Damage Repair

    Updated: 2024-04-19 18:56:18
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 19th , 2024 Parkinson's Disease in the SENS View of Damage Repair Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The Strategies for Engineered Negligible Senescence SENS is a view of aging as accumulated damage . Drawing from the extensive scientific

  • Bis(monoacylglycero)phosphates Accumulate in Aged Tissues

    Updated: 2024-04-19 10:11:34
    Lipid metabolism is changed and disrupted with advancing age, as is the case for all complex mechanisms in the body. There are a great many different lipids present in the body; even the list of classes of lipid is a long one. Finding specific changes that relate to aging can be interesting, but the challenge lie in better understanding how those changes come about, and whether they causes significant harm to tissues. Many age-related changes in molecular biochemistry are far downstream of the important causes of aging and do not cause much further disruption in and of themselves. In recent years, laboratory research has shown that we may be able to counteract age-related diseases by intervening in the fundamental processes that lead to ageing. Although […]

  • MKP1 as a Target for Idiopathic Pulmonary Fibrosis

    Updated: 2024-04-19 10:10:13
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 19th , 2024 MKP1 as a Target for Idiopathic Pulmonary Fibrosis Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The causes of idiopathic pulmonary fibrosis remain somewhat unclear , which is often the case for conditions in which treatments struggle to

  • Endothelial Cellular Senescence Contributes to Loss of Capillary Density

    Updated: 2024-04-18 18:44:14
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 18th , 2024 Endothelial Cellular Senescence Contributes to Loss of Capillary Density Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The consensus of the research community on senescent cells in old tissues is that a their presence causes harm , and b

  • Gut Microbiome Composition Correlates with Longevity in Rabbits

    Updated: 2024-04-18 10:22:15
    Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help April 18th , 2024 Gut Microbiome Composition Correlates with Longevity in Rabbits Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The balance of microbial populations making up the gut microbiome is different from individual to individual , and changes with

  • An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis

    Updated: 2024-04-18 10:11:59
    As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The burden of established plaque correlates with mortality risk, but repeatable, sizable reversal of plaque in patients cannot be achieved by the current […]

  • Calorie restriction study reveals complexities in how diet impacts aging

    Updated: 2024-04-17 22:28:16
    The rate at which human cells age is influenced by multiple interconnected factors. New research examined how restricting calories influences telomere length and biological aging.

  • Researchers find that accelerated aging biology in the placenta contributes to a rare form of pregnancy-related heart failure

    Updated: 2024-04-17 22:27:03
    In a new study, researchers show that elevated levels of proteins related to cellular senescence, or aging, in the blood and the placenta are linked to this form of heart failure.

  • Human muscle map reveals how we try to fight effects of aging

    Updated: 2024-04-15 15:05:38
    The first comprehensive cell atlas of aging human muscle reveals the intricate genetic and cellular processes behind muscle deterioration and mechanisms to counteract it.

  • Impact of aldehydes on DNA damage and aging

    Updated: 2024-04-10 15:27:17
    Researchers have discovered the connection between aldehydes, organic compounds produced by cells as part of metabolic processes, and rapid aging. Their findings indicate a potential treatment for diseases that lead to accelerated aging as well as a means to counteract aging in healthy people by controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.

  • Scientists identify pro-aging 'sugar signature' in the blood of people living with HIV

    Updated: 2024-04-10 15:27:06
    Scientists have identified sugar abnormalities in the blood that may promote biological aging and inflammation in people living with HIV.

  • Pregnancy accelerates biological aging in a healthy, young adult population

    Updated: 2024-04-08 19:04:49
    Pregnancy may carry a cost, reports a new study. The research shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies.

  • RNA that doesn't age

    Updated: 2024-04-05 17:04:46
    Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists have now demonstrated that this. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions. The research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.

  • Blended antioxidant supplement improves cognition and memory in aged mice

    Updated: 2024-04-02 18:03:21
    Cell damage from oxidative stress is a major underlying cause of age-related cognitive and muscle strength decline. Antioxidants can reduce oxidative stress and prevent age-related health decline. A new study has found that mice administered with a blended antioxidant supplement show significant improvements in spatial cognition, short-term memory, and mitigated age-related muscle decline. The study suggests that blended antioxidant supplements hold promise as a dietary intervention for health issues associated with aging.

  • Familial Alzheimer's disease transferred via bone marrow transplant in mice

    Updated: 2024-03-28 15:10:45
    Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease -- and at an accelerated rate.

  • Risk factors for faster aging in the brain revealed in new study

    Updated: 2024-03-27 04:47:03
    Researchers have used data from UK Biobank participants to reveal that diabetes, traffic-related air pollution and alcohol intake are the most harmful out of 15 modifiable risk factors for dementia.

  • Researchers discover a mechanism that could improve platinum-based cancer therapy

    Updated: 2024-03-27 04:46:15
    Researchers say they have discovered that the protein puromycin-sensitive aminopeptidase (NPEPPS) plays a role in regulating response to platinum chemotherapy in patients with bladder cancer.

  • Researchers show that introduced tardigrade proteins can slow metabolism in human cells

    Updated: 2024-03-26 21:00:55
    Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.

  • Common degenerative brain disease may begin to develop in middle age

    Updated: 2024-03-26 14:39:10
    Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study. In the study, almost one in ten of over 50-year-olds were found to have tissue markers of Lewy body disease in the brain.

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