Updated: 2023-01-31 11:11:15
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 31st , 2023 A Discussion of the Biochemistry of Cardiac Fibrosis Permalink No Comments Yet Add a Comment Posted by Reason Fibrosis is a malfunction of tissue maintenance , in which excessive amounts of extracellular matrix structure are created , forming scar-like features that disrupt normal
Updated: 2023-01-31 11:11:11
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 31st , 2023 Obesity Considerably Raises the Risk of Later Life Frailty Permalink No Comments Yet Add a Comment Posted by Reason As might be expected , epidemiological data shows that obesity in mid-life raises the risk of suffering frailty in later life . Excess visceral fat tissue increases the
Updated: 2023-01-30 20:17:13
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 30th , 2023 Does Mitochondrial Dysfunction Meaningfully Contribute to the Development of Atherosclerosis Permalink No Comments Yet Add a Comment Posted by Reason Mitochondria are the power plants of the cell , producing the chemical energy store molecule ATP but are also integrated into a wide
Updated: 2023-01-30 11:22:25
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 30th , 2023 Antihypertensive Drug Rilmenidine is a Calorie Restriction Mimetic Permalink Read 1 Comment Add a Comment Posted by Reason Researchers here use nematode worms to demonstrate that a commonly used antihypertensive drug is a calorie restriction mimetic The beneficial response to calorie
Updated: 2023-01-30 11:04:24
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 30th , 2023 Extracellular Vesicles in the Development of Neurodegenerative Conditions Permalink No Comments Yet Add a Comment Posted by Reason A broad discussion of extracellular vesicles is really a broad discussion of cell communication , as much of the traffic of molecules between cells is
Updated: 2023-01-29 14:03:21
, Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 29th , 2023 Fight Aging Newsletter , January 30th 2023 Permalink No Comments Yet Add a Comment Posted by Reason Fight Aging publishes news and commentary relevant to the goal of ending all age-related disease , to be achieved by bringing the mechanisms of aging under the control of modern
Updated: 2023-01-27 20:11:58
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 27th , 2023 Towards Microneedle Delivery of LNP-mRNA Gene Therapies for Skin Aging Permalink No Comments Yet Add a Comment Posted by Reason The skin is arguably one of the easiest of the large organs in the body to target for delivery of gene therapies via established microneedle approaches .
Updated: 2023-01-27 11:22:23
If I'm understanding the results presented here correctly, the reversine small molecule enables senescent cells to return to a more normal state of function, including replication, at least in muscle cells examined in cell culture. The researchers believe it is triggering some of the same reprogramming pathways as the Yamanaka factors, perhaps by inducing expression of Oct4, but are not yet certain as to what is going on under the hood. Is it a good idea to take senescent cells in the body and return them to normal function? That is a good question, and has been raised for other approaches to senescence reversal. At least some senescent cells are senescent for a good reason, being damaged in ways that may lead to cancer, and […]
Updated: 2023-01-27 11:11:50
Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help January 27th , 2023 Osteopontin Plays Diverse Roles in Degenerative Aging Permalink No Comments Yet Add a Comment Posted by Reason Osteopontin levels are higher in blood samples taken from older people than in those taken from young people . It is a component of the senescence-associated secretory
Updated: 2023-01-26 18:39:13
The comparative biology of aging, the study of aging in species with widely divergent life spans, is hoped to improve the catalog and understanding of important mechanisms of aging. It may or may not turn out to be the case that the biochemistry of long-lived species can give rise to practical therapies that slow aspects of human aging, at least in the near future of the next few decades. Engineering a human that ages more slowly seems a far more daunting task than the production of rejuvenation therapies that repair the known forms of cell and tissue damage that drive aging. An alternative to comparing other species with humans is to take a collection of closely related species with divergent life spans and attempt to […]
Updated: 2023-01-26 15:02:45
People with early cardiovascular disease may be more likely to have memory and thinking problems and worse brain health in middle age, according to new research.
Updated: 2023-01-25 13:58:31
Senior women were less likely to develop mild cognitive impairment or dementia if they did more daily walking and moderate-to-vigorous physical activity.
Updated: 2023-01-23 05:33:04
Researchers have found that the drug rilmenidine can extend lifespan and slow aging.
Updated: 2023-01-20 20:49:24
The sport of orienteering, which draws on athleticism, navigational skills and memory, could be useful as an intervention or preventive measure to fight cognitive decline related to dementia, according to new research.
Updated: 2023-01-19 00:57:17
High blood pressure and diabetes are known risk factors for stroke, but now a new study shows that the amount of risk may decrease as people age.
Updated: 2023-01-18 00:29:18
Researchers compared aging mice that had access to a weighted exercise wheel with mice that had undergone epigenetic reprogramming via the expression of Yamanaka factors. Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming.
Updated: 2023-01-14 19:27:47
Hormone Replacement Therapy (HRT) could help prevent Alzheimer's Dementia among women at risk of developing the disease -- according to new research.
Updated: 2023-01-12 23:21:08
Human cells with impaired mitochondria ramp up their metabolism to enhance short-term survival, but at a cost: more rapid aging.
Updated: 2023-01-12 16:32:24
In two studies using nationally representative data gathered on thousands of Americans, researchers have significantly added to evidence that social isolation is a substantial risk factor for dementia in community-dwelling (noninstitutionalized) older adults, and identified technology as an effective way to intervene.
Updated: 2023-01-12 14:09:36
A new study has shed light on the many and varied fall-risk factors facing older adults in community-living environments. The research examined a comprehensive set of potential fall-risk factors -- including environmental factors, in addition to health and function -- in older community-living adults in the U.S., both with and without dementia.
Updated: 2023-01-10 20:09:43
A new study has found that older adults with greater severity of hearing loss were more likely to have dementia, but the likelihood of dementia was lower among hearing aid users compared to non-users.
Updated: 2023-01-10 15:34:50
Researchers have identified a new mechanism behind knee osteoarthritis, showing that increased stiffening in the extracellular matrix led to a decrease in the Klotho 'longevity protein,' which led to damage in healthy cartilage cells. The findings may inform better treatment targets and increase understanding of other conditions caused by aging tissues in the body.
Updated: 2023-01-10 15:34:13
In a study using data from nearly 1,200 older adults, researchers have added to a growing body of evidence that loss of the sense of smell is a predictive marker for an increased risk of frailty as people age.
Updated: 2023-01-05 20:13:46
Researchers are studying how the reduction of a gene variant found in the brain's immune cells could diminish the risk of late-onset Alzheimer's disease.
Updated: 2023-01-05 20:12:13
Researchers investigated the role of one cellular mechanism in improving physical fitness by exercise training and identified one anti-aging intervention that delayed the declines that occur with aging in the model organism. Together, the scientists' findings open the door to new strategies for promoting muscle function during aging.
