Adoptive cell therapies involve introducing immune cells to attack a specific issue in the body, most often cancer. The earliest forms of adoptive cell therapy used immune cells from another individual, but more modern approaches use a patient's own cells, expanded in culture and potentially engineered in various ways. Think of chimeric antigen receptor T cell (CAR-T) therapies, for example. Both T cells and natural killer (NK) cells have been employed as a basis for adoptive cell therapies targeted at cancer. In today's open access paper, researchers consider another potential use for adoptive NK cell therapy, as a way to produce lasting clearance of senescent cells in aged tissues. It is clear that NK cells, along with several other immune cell types, are involved in […]

The practice of calorie restriction, reducing calorie intake by up to 40% while still obtaining a sufficient level of micronutrients necessary to good health, is well demonstrated to slow aging. It slows near all aspects of aging and progression of near all age-related conditions, and so the literature is packed with papers that investigate just one of those line items. Here, the focus is on loss of bone mineral density with age, a phenomenon that leads to osteoporosis and eventual fracture and incapacity. This is one of the few age-related conditions for which there is some debate over whether moderate or greater calorie restriction is a net benefit, based on apparently contradictory animal data. My impression of the literature, reinforced here, is that the weight […]

The measurement of life span is self-evident and obvious, but is little consensus on how to measure healthspan, the length of life spent in good health. Good health is like art, we know it when we see it, but that isn't helpful when trying to compare the effects of interventions where the studies were conducted by different researchers with different ideas as what constitutes good health in an older individual. This issue exists for both human and animal studies, and the lack of consistency makes it hard to make comparisons based on the existing literature on the topic. Researchers are starting to propose rigorous definitions of healthspan, but it seems that we stand some distance removed from any great agreement as to which of these […]

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 25th , 2024 Considering the Gut Microbiome as a Contributing Factor in Living to 100 Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment What are the biological mechanisms by which centenarians manage to reach 100 years of age or more , significantly outliving

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 25th , 2024 Immunopeptide PEPITEM can Reduce Chronic Inflammatory Reactions in Old Mice Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Researchers here describe an injected immunomodulatory peptide that reduces migration of adaptive immune cells in

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 25th , 2024 Limbic-predominant Amnestic Neurodegenerative Syndrome May Be a TDP-43 Pathology Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment The aging brain malfunctions in complex ways , giving rise to a range of poorly categorized end states beyond the

People with high levels of body fat stored in their belly or arms may be more likely to develop diseases like Alzheimer's and Parkinson's than people with low levels of fat in these areas, according to new research. The study also found that people with a high level of muscle strength were less likely to develop these diseases than people with low muscle strength.

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 24th , 2024 PKM2 Aggregation as a Pathological Mechanism in Senescent Cells Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Senescent cells accumulate with age throughout the body . Cellular senescence occurs most often at the end of a cell's replicative

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 24th , 2024 Improving Mitochondrial Function to Slow or Reverse Ovarian Aging Permalink With Comments Permalink No Comments Posted by Reason Read 1 Comment Add a Comment Mitochondria are the power plants of the cell , their production of the chemical energy store molecule adenosine triphosphate ATP

Home FAQ Fund Research Services Investing Therapies Newsletter Archives Press Room Resources About Fight Aging Do you want to live a longer life in good health Simple practices can make some difference , such as exercise or calorie restriction . But over the long haul all that really matters is progress in medicine : building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive , the more lives will be saved . Find out how to help July 24th , 2024 Towards mRNA Therapies to Clear Intracellular Protein Aggregates Permalink With Comments Permalink No Comments Posted by Reason No Comments Yet Add a Comment Here find a SENS Research Foundation article covering some of the specifics of progress towards messenger RNA mRNA therapies

Atherosclerosis is the development of fatty plaques in blood vessel walls. It is a universal condition of aging, present to some degree in every older individual. Atherosclerosis contributes to many age-related diseases via narrowing of vessels and reduced blood flow on the one hand, and on the other causing more than a quarter of all human mortality via the stroke and heart attack that can follow rupture of an unstable plaque. We might think of atherosclerosis as a condition of macrophage dysfunction. Macrophages are innate immune cells responsible for clearing excess cholesterol from blood vessel walls. These cells ingest cholesterol and the LDL particles that transport cholesterol from the liver to the rest of the body. Then then hand off that cholesterol to HDL particles […]

A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against 'inflammageing', which is widely believed to be the root cause of many age-related diseases. A study raises the exciting possibility of a protective agent that could dampen age-related inflammation and restore normal immune function in older adults.

Researchers have found that intense stress can be felt at the cellular level and is linked to negative physical and mental health effects.

Researchers have established new criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. It can often be mistaken for Alzheimer's disease.

Scientists have discovered that 'switching off' a protein called IL-11 can significantly increase the healthy lifespan of mice by almost 25 percent.

In a new analysis of data, researchers have found that taking a daily supplement containing antioxidant vitamins and minerals slows progression of late-stage dry age-related macular degeneration (AMD), potentially helping people with late-stage disease preserve their central vision.

Hormone modulating therapy (HMT) used for the treatment of breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias later in life, according to a new study.

Research reveals how brain inflammation triggers extreme muscle weakness across several diseases, including viral infection, bacterial infection and Alzheimer's disease. The study, in fruit flies and mice, also identified ways to block this process, which could have implications for treating or preventing the muscle wasting sometimes associated with inflammatory diseases, including bacterial infections, Alzheimer's disease and long COVID.

Scientists investigating Alzheimer's disease have determined the structure of molecules within a human brain. Their study describes how scientists used cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer's disease donor brain. This gave 3-dimensional maps in which they could observe proteins within the brain.

A new study looks at predicting how quickly people with early Alzheimer's disease will experience cognitive decline. The study also looked at how the new drugs recently approved for the disease may reduce decline.

A longitudinal study has found that high-intensity interval exercise improves brain function in older adults for up to 5 years.

Drosophila -- known as fruit flies -- are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction to calculate cardiac dynamics. Researchers now show a way to significantly cut the time needed for that analysis while utilizing more of the heart region, using deep learning and high-speed video microscopy.

Young adults who have higher levels of inflammation, which is associated with obesity, physical inactivity, chronic illness, stress and smoking, may experience reduced cognitive function in midlife, a new study has found.

Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a 'one-size-fits-all' remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings publishing July 2 in Nature Medicine.

A colder nose and warmer cheeks may be a telltale sign of rising blood pressure. Researchers discovered that temperatures in different face regions are associated with various chronic illnesses, such as diabetes and high blood pressure. These temperature differences are not easily perceptible by one's own touch but can instead be identified using specific AI-derived spatial temperature patterns that require a thermal camera and a data-trained model. With further research, doctors could one day use this simple and non-invasive approach for early detection of diseases.