Updated: 2024-01-22 06:36:55
Cytometry Part A, Volume 105, Issue 1, Page 10-15, January 2024.
Updated: 2024-01-18 21:09:09
Skip to content Explore CRI's 2023 Cancer Research Impact Why CRI Our Purpose Our Mission Our Impact Impact 2023 Our Approach Overview CRI Network CRI Discovery CRI Trials CRI Informatics Our Leadership Scientific Advisory Council Board of Trustees Associate Board Our Team About CRI Timeline of Discovery History DEI Commitment Philanthropic Awards Charity Ratings and Reporting Resources Events Blog Media Room Annual Reports FAQs This is your opportunity to help create a world immune to cancer Join us and the worldâ s leading scientists in the pursuit of life saving immunotherapies that will forever change how we treat cancer , from the inside . out DONATE NOW Immunotherapy Overview Immunotherapy at a Glance Immunotherapy In-Depth Resource Center Immunotherapy by Cancer Type Immunotherapy
Updated: 2024-01-18 21:09:09
: Skip to content Explore CRI's 2023 Cancer Research Impact Why CRI Our Purpose Our Mission Our Impact Impact 2023 Our Approach Overview CRI Network CRI Discovery CRI Trials CRI Informatics Our Leadership Scientific Advisory Council Board of Trustees Associate Board Our Team About CRI Timeline of Discovery History DEI Commitment Philanthropic Awards Charity Ratings and Reporting Resources Events Blog Media Room Annual Reports FAQs This is your opportunity to help create a world immune to cancer Join us and the worldâ s leading scientists in the pursuit of life saving immunotherapies that will forever change how we treat cancer , from the inside . out DONATE NOW Immunotherapy Overview Immunotherapy at a Glance Immunotherapy In-Depth Resource Center Immunotherapy by Cancer Type
Updated: 2024-01-17 00:49:46
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Skip to content Find a Condition Find a Physician Find a Location Make an Appointment Health Science News Give Comer Children's Hospital Search Menu Patients Visitors Healthcare Professionals Research Clinical Trials : Appointments 1-888-824-0200 See All Patient Visitor Information All Specialties Services Cancer Gastroenterology GI Heart Vascular LGBTQ+ Care Services Neurology Neurosurgery OB GYN Orthopaedics Pediatrics Surgery Transplant Patient Information Billing Financial Assistance Classes Events Contact Us Insurance Information International Patients Visiting Us From Out of State Online Second Opinions Price Transparency Request Medical Records Video Visits Visitor Information Dining Options Gift Shop Locations Directions Our Neighborhood City Visitor's Guide Magnet Site Visit :
Updated: 2024-01-11 15:03:41
Skip to content Find a Condition Find a Physician Find a Location Make an Appointment Health Science News Give Comer Children's Hospital Search Menu Patients Visitors Healthcare Professionals Research Clinical Trials : Appointments 1-888-824-0200 See All Patient Visitor Information All Specialties Services Cancer Gastroenterology GI Heart Vascular LGBTQ+ Care Services Neurology Neurosurgery OB GYN Orthopaedics Pediatrics Surgery Transplant Patient Information Billing Financial Assistance Classes Events Contact Us Insurance Information International Patients Visiting Us From Out of State Online Second Opinions Price Transparency Request Medical Records Video Visits Visitor Information Dining Options Gift Shop Locations Directions Our Neighborhood City Visitor's Guide Magnet Site Visit :
Updated: 2024-01-07 06:47:29
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them. (Source: Fight Aging!)
Updated: 2024-01-07 06:47:28
In conclusion, inhibiting the lysosomal oxidation of LDL in atherosclerotic lesions by antioxidants targeted at lysosomes causes the regression of atherosclerosis and improves liver and muscle characteristics in mice and might be a promising novel therapy for atherosclerosis in patients.
NANOG Expression versus Cellular Senescence
https://www.fightaging.org/archives/2021/09/nanog-expression-versus-cellular-senescence/
Are there many strategies that can reverse cellular senescence? There are certainly strategies that can lower levels of cellular senescence over time, both in cell cultures and in living animals, but very few are actually reprogramming senescent cells into normal cells. It isn't clear that this reversal of the senescent state is a good idea, given that ther...
Updated: 2024-01-07 06:47:28
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit:
https://www.fightaging.org/newsletter/
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Contents
Age-Related Dysfunction in Cellular Metabolism Substantially Impacts the Immune System
Procaine as an ...
Updated: 2024-01-07 06:47:27
The age-related decline of the immune system is complex. There are many facets to the issues of increased systemic inflammation and reduced immune competence. Here, researchers show that a necessary population of memory B cells is reduced with age, and this impairs the ability of the immune system to respond to novel threats. Clearing the entire B cell complement has been attempted in mice, and shown to improve function. B cells regenerate rapidly following clearance, even in old animals. It is as yet unknown as to how that approach interacts with the dysfunction described here, but B cell clearance does address the problem of an accumulation of dysfunctional age-associated B cells.
Immunological memory is the ability of our immune system to remember previously encountered pathoge...
Updated: 2024-01-07 06:47:26
Home About MedWorm Health News Specialties Conditions Cancers Infec . Diseases Procedures Therapies Nutrition Drugs Vaccines Management Training Countries any words all words exact phrase advanced f29c Advanced search can include the : following OR operator : NOT operators : OR phrase search : breast cancer AND is implied so listing two words without another operator will search for records where both words are . present use to group words : together eg . cancer cancers cervical cervix Squamous cell carcinoma SCC will return records where either the words cancer' or cancers' are present , plus the words cervical' or cervix' , but not the phrase squamous cell carcinoma' or . SCC' order operator : word1 eg . chronic leukaemia here the word chronic' must come somewhere before either the work
Updated: 2024-01-07 06:47:26
, Home About MedWorm Health News Specialties Conditions Cancers Infec . Diseases Procedures Therapies Nutrition Drugs Vaccines Management Training Countries any words all words exact phrase advanced f29c Advanced search can include the : following OR operator : NOT operators : OR phrase search : breast cancer AND is implied so listing two words without another operator will search for records where both words are . present use to group words : together eg . cancer cancers cervical cervix Squamous cell carcinoma SCC will return records where either the words cancer' or cancers' are present , plus the words cervical' or cervix' , but not the phrase squamous cell carcinoma' or . SCC' order operator : word1 eg . chronic leukaemia here the word chronic' must come somewhere before either the
Updated: 2024-01-07 06:47:25
Home About MedWorm Health News Specialties Conditions Cancers Infec . Diseases Procedures Therapies Nutrition Drugs Vaccines Management Training Countries any words all words exact phrase advanced f29c Advanced search can include the : following OR operator : NOT operators : OR phrase search : breast cancer AND is implied so listing two words without another operator will search for records where both words are . present use to group words : together eg . cancer cancers cervical cervix Squamous cell carcinoma SCC will return records where either the words cancer' or cancers' are present , plus the words cervical' or cervix' , but not the phrase squamous cell carcinoma' or . SCC' order operator : word1 eg . chronic leukaemia here the word chronic' must come somewhere before either the work
Updated: 2024-01-07 06:47:25
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
A Great Deal of Work Lies Ahead in the Development of In Vivo Reprogramming as a Therapy
Thinking of ...
Updated: 2024-01-07 06:47:24
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Updated: 2024-01-07 06:47:24
We’re hosting a webinar for students and fellows interested in the Postdoctoral Research Associate Training (PRAT) program for the October 4, 2021, receipt date:
Tuesday, June 22, 2:00-3:00 p.m. ET
PRAT is a competitive 3-year fellowship program that prepares trainees for leadership positions in biomedical careers. Training includes a mentored laboratory research experience and intensive career and leadership development activities. PRAT fellows conduct research in laboratories in the NIH Intramural Research Program (IRP) in basic biomedical research areas within the NIGMS mission. These areas include, but are not limited to, biological chemistry, biophysics, bioinformatics, cellular and molecular biology, computational biosciences, developmental biology, genetics, immunology...
Updated: 2024-01-07 06:47:24
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cause harm via their signaling, a good fraction of which is carried via forms of extracellular vesicle, such as exosomes. Here, researchers review what is known of the signal...
Updated: 2024-01-07 06:47:22
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)MedWorm Message:
Updated: 2024-01-07 06:47:22
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Updated: 2024-01-07 06:47:20
In conclusion, PLG attenuates high calcium/phosphate-induced vascular calcification by upregulating P53/PTEN signaling in VSMCs.
Tsimane and Moseten Hunter-Gatherers Exhibit Minimal Levels of Atrial Fibrillation
https://www.fightaging.org/archives/2021/03/tsimane-and-moseten-hunter-gatherers-exhibit-minimal-levels-of-atrial-fibrillation/
Epidemiological data for the Tsimane and Moseten populations in Bolivia shows that they suffer very little cardiovascular disease in later life, despite a presumably greater lifetime burden of infectious disease (and consequent inflammation) than is the case for people in wealthier regions. The differences in lifestyle are fairly straightforward: a much greater level of physical activity throughout life, and a diet that is high in fiber ...
Updated: 2024-01-07 06:47:20
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Updated: 2024-01-07 06:47:20
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The Role of Reactive Oxygen Species in Aging is Complex
https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-aging-is-complex/
Every compound and aspect of biology has a dose-response relationship of some sort. Wildly different outcomes should be expected at different level...
Updated: 2024-01-07 06:47:20
Cancers subvert the immune system in a variety of ways, such as in order to aid growth, or suppress the immune response normally triggered by the presence of cancerous cells. Regulatory T cells are involved in halting the immune response after it is has done its job, and in preventing autoimmunity, in which the immune system attacks the body. This role is abused in cancerous tissue in order to protect the cancer from the immune system. Researchers here identify some of the controlling biochemistry that makes regulatory T cells behave differently in this scenario. The mechanism appears distinct enough, operating only in cancerous tissue, to be a good basis for the development of therapies that could in principle strip much of this protection from a cancer.
Immunologists have discov...
Updated: 2024-01-07 06:47:19
: Home About MedWorm Health News Specialties Conditions Cancers Infec . Diseases Procedures Therapies Nutrition Drugs Vaccines Management Training Countries any words all words exact phrase advanced f29c Advanced search can include the : following OR operator : NOT operators : OR phrase search : breast cancer AND is implied so listing two words without another operator will search for records where both words are . present use to group words : together eg . cancer cancers cervical cervix Squamous cell carcinoma SCC will return records where either the words cancer' or cancers' are present , plus the words cervical' or cervix' , but not the phrase squamous cell carcinoma' or . SCC' order operator : word1 eg . chronic leukaemia here the word chronic' must come somewhere before either the
Updated: 2024-01-07 06:47:19
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immune system is more prone to a sustained inflammatory response, provoked by pro-inflammatory signaling of senescent cells and the signs of cell damage that circulate in the b...
Updated: 2024-01-07 06:47:19
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
Link: https://doi.org/10.14336/AD.2020.0320 (Source: Fight Aging!)MedWorm Message:
Updated: 2024-01-07 06:47:19
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and were virtually unchanged after adjustment for a large set of sociodemographic, lifestyle, and anthropometric variables.
Inhibition of GLS1 Selectively Destroys S...
Updated: 2024-01-07 06:47:19
In recent years, a great deal of attention has been devoted to the role of the gut microbiome in aging, as populations shift to include fewer helpful and more harmful microbes. In particular, the ability of the gut microbiome to influence the state of chronic inflammation in aging may be at least as important as lifestyle choices such as degree of exercise. Expanding this line of thinking, researchers here look at the macrobiome, small parasitic animals that dwell in the gut, and their role in age-related inflammation.
A new review looks at the growing evidence to suggest that losing our 'old friend' helminth parasites, which used to live relatively harmlessly in our bodies, can cause ageing-associated inflammation. It raises the possibility that carefully controlled, restorative ...
Updated: 2024-01-07 06:47:18
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Updated: 2024-01-07 06:47:18
The intensive care unit nurse was worried the COVID-19 vaccine would kill her. In the past, just minutes after getting the influenza vaccine, she had hives, wheezing, and throat swelling. Her life-threatening reaction only resolved after an epinephrine injection and monitoring in the emergency room. She vowed never to get another vaccine. With the arrival […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Updated: 2024-01-07 06:47:17
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Updated: 2024-01-07 06:47:16
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Updated: 2024-01-07 06:47:16
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Updated: 2024-01-07 06:47:15
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging.
Senescent Cells Fail to Maintain Proteostasis
https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking place than was previously the case. In many cases it isn't all that clear as to whether an incrementally greater understanding of mechanism A or mechanism B will at any poin...
Updated: 2024-01-06 22:10:33
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Updated: 2024-01-06 22:10:33
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join us on as we delve into the world of mast cell disorders, including the lesser-understood mast cell activation syndrome (MCAS). Our guest, Kara Wada, a board-certified academic adult and pediatric allergy, immunology, and lifestyle medicine physician, will shed light on the complexities of
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Unraveling the mysteries of mast cell disorders [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Updated: 2024-01-06 22:10:32
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
https://www.fightaging.org/archives/2023/12/klotho-as-a-biomarker-of-the-influence-of...
Updated: 2024-01-06 22:10:32
Home About MedWorm Health News Specialties Conditions Cancers Infec . Diseases Procedures Therapies Nutrition Drugs Vaccines Management Training Countries any words all words exact phrase advanced f29c Advanced search can include the : following OR operator : NOT operators : OR phrase search : breast cancer AND is implied so listing two words without another operator will search for records where both words are . present use to group words : together eg . cancer cancers cervical cervix Squamous cell carcinoma SCC will return records where either the words cancer' or cancers' are present , plus the words cervical' or cervix' , but not the phrase squamous cell carcinoma' or . SCC' order operator : word1 eg . chronic leukaemia here the word chronic' must come somewhere before either the work
Updated: 2024-01-06 22:10:31
“A child is born with a food allergy. They do not choose to have their immune system compromised. Parents do not get the choice to opt-in or out of having their child ’s body recognize ordinary food as a threat. Food allergies are a unique disease in that we need the help of those around usRead more …When celebrities attack children with food allergies [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Updated: 2024-01-06 22:10:31
In conclusion, premature thymic involution and chronic inflammation greatly contribute to increased morbidity and mortality in CKD patients. Mechanisms are likely to be multiple and interlinked. Even when the quest to fountain of youth is a pipe dream, there are many scientific opportunities to prevent or to, at least in part, reverse CKD-related immune senescence. Further studies should precisely define most important pathways driving premature immune ageing in CKD patients and best therapeutic options to control them.
Extending Life Without Extending Health: Vast Effort Directed to the Wrong Goals
https://www.fightaging.org/archives/2021/09/extending-life-without-extending-health-vast-effort-directed-to-the-wrong-goals/
It is very hard to coax a damaged machine into co...
Updated: 2024-01-05 09:44:30
Cytometry Part A, EarlyView.